Results 151 to 160 of about 1,228,948 (249)

A User-Centered Interface Design Framework for the DELONELINESS System in Older Adults: Design Indicator Development and Prioritization.

JMIR Hum Factors
Zhou Y, Rees J, Matcham F, Antonelli M, Ourselin S, Liu W.   +5 more
europepmc   +1 more source

Laboratory study on the deformation resistance indicators of asphalt mixture based on the rutting deformation growth model. [PDF]

PLoS One
Liu L, Sun Z.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Development and 2025 re-evaluation of a Japanese quality indicator set for adult intensive care: a modified RAND/UCLA Delphi study. [PDF]

J Intensive Care
Kumasawa J, Okamoto H, Naito T, Asaga T, Kimura M, Kotani T, Komatsu Y, Suzuki T, Takahashi T, Takei T, Nishimura M, Hashimoto S, Yamaguchi H, Doi M.   +13 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effective coverage practice in Ethiopia. [PDF]

BMJ Glob Health
Lemma S, Berhanu AT, Tadele A, Yihun B, Yakob B, Melesse DY, Getachew F, Tollera G, Achamyeleh H, Arba MA, Getnet M, Schellenberg J, Exley J, Alemu K, Persson LÅ, Guadu T, Getachew T, Denu ZA, Mullisa Z, Marchant T, Effective coverage technical working group, Abc.   +21 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Developing a Service Quality Index System for AI Health Care Chatbots: Mixed Methods Study.

J Med Internet Res
Gu Y, Wang X.
europepmc   +1 more source

Ranked Severe Maternal Morbidity Index for Population-Level Surveillance by Mode of Delivery. [PDF]

J Womens Health (Larchmt)
Womack LS, Galang RR, Admon LK, Clark EA, Ewing AC, Satten GA, Ko JY, Ferre CD, Kroelinger CD.   +8 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source