Results 71 to 80 of about 142,903 (317)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Creation and study of formulations as inhibitors of metal corrosion and scaling for stabilization water treatment in water utilization systems (a review) [PDF]

, 2016
This review summarizes studies for the past 5 years aimed at creation of efficient organophosphonate reagents for the stabilization water treatment aimed at preventing metal corrosion and scaling in water utilization systems.This study was carried out ...
Bolt, Y. V., Dernovaya, E. S., Driker, B. N., Fetisova, T. S., Tsirulnikova, N. V.   +4 more
core  

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Detection of cellulolytic fungi by using Congo red as an indicator: a comparative study with the dinitrosalicyclic acid reagent method

Journal of Applied Bacteriology, 1986
Cellulolytic fungi can easily be screened within 2 d for the production of cellulolytic enzymes by staining with Congo red, or by measuring the amount of reducing sugar (glucose) produced with the dinitrosalicyclic acid reagent method. Endoglucanase activity is visible in carboxymethyl cellulose agar plates after staining with Congo red, and fixing ...
SAZCI, A, RADFORD, A, ERENLER, K
openaire   +4 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Application of quality monitoring indicators of blood testing in blood banks of Shandong province

Zhongguo shuxue zazhi
Objective To objectively evaluate the quality control level of blood testing process in blood banks through quantitative monitoring and trend analysis, and to promote the homogenization level and standardized management of blood testing laboratories in ...
Xuemei LI, Weiwei ZHAI, Zhongsi YANG, Shuhong ZHAO, Yuqing WU, Qun LIU, Zhe SONG, Zhiquan RONG, Shuli SUN, Xiaojuan FAN, Wei ZHANG, Jinyu HAN, Lin ZHU, Xianwu AN, Hui ZHANG, Junxia REN, Xuejing LI, Chenxi YANG, Bo ZHOU, Haiyan HUANG, Guangcai LIU, Ping CHEN, Hui YE, Mingming QIAO, Hua SHEN, Dunzhu GONGJUE, Yunlong ZHUANG   +26 more
doaj   +1 more source

Scale for coping strategies for informal caregivers of patients with cancer

Psicooncologia, 2017
Objective: Analize the psychometric properties of a new instrument valid and reliable instrument, which assesses the coping strategies in informal primary caregivers (IPC) of patients with cancer.
Fatima Sagrario Espinoza-Salgado, Isabel Reyes-Lagunes, Eduardo Velasco-Rojano, María Cristina Bravo-González, Armando Ramírez Ramírez   +4 more
doaj   +1 more source

Sustainability Capacity of HIV/AIDS Programmes in YOGYAKARTA, Indonesia [PDF]

, 2017
The Indonesian government established the prevalence target of HIV <0.50% in 2019 to control the spreading of HIV through the National Medium Term Development Plan.
Mahendradhata, Y. (Yodi), Sebong, P. (Perigrinus), Sulistio, D. H. (Dwi)   +2 more
core   +2 more sources