Results 191 to 200 of about 148,518 (279)

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

open access: yesDrug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan   +4 more
wiley   +1 more source

Discomfort Avoidance and Desire for Normality Are Decision‐Making Drivers of Footwear Choice in Underserved Communities at Risk of Diabetic Foot Ulcer

open access: yesJournal of Foot and Ankle Research, Volume 19, Issue 3, September 2026.
ABSTRACT Background Diabetes‐related foot ulceration (DFU) is a serious complication that can lead to lower limb amputation or death. Custom‐made footwear is a key preventative strategy, yet adherence to use is often low. The factors influencing decision‐making for footwear use remain unclear, particularly among underserved groups such as people from ...
Krithika Anil   +8 more
wiley   +1 more source

Open letter: The need for a site‐based biodiversity standard measuring and certifying impacts from nature‐based projects

open access: yesPLANTS, PEOPLE, PLANET, Volume 8, Issue 5, Page 1394-1402, September 2026.
Despite growing investment in restoration, weak accountability and poor biodiversity monitoring mean many projects fail to achieve ecological recovery. The Global Biodiversity Standard (TGBS) offers a practical way to ensure that restoration finance delivers measurable gains for nature.
David Bartholomew   +254 more
wiley   +1 more source

Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members

open access: yesProtein Science, Volume 35, Issue 9, September 2026.
Abstract Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional diversity but also permits
Harshita Sawdekar   +6 more
wiley   +1 more source

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