Metagenomic and metabolite analysis reveals microbial community and metabolite dynamics in fermented Indigo naturalis [PDF]
HeliyonThe soaking and fermentation of the stems and leaves is an important intermediate step in the processing of Indigo Naturalis. However, the relationship between microbiota and Indigo Naturalis yields is still poorly understood. This study aimed to compare
Jihai Gao, Feixia Hou
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Treatment-refractory ulcerative colitis responsive to indigo naturalis [PDF]
BMJ Open Gastroenterology, 2021 Background Indigo naturalis (IN) is an herbal medicine that has been used for ulcerative colitis with an unclear mechanism of action. Indigo and indirubin, its main constituents, are ligands of the aryl hydrocarbon receptor (AhR). We assessed the safety,
Berkeley Limketkai +7 more
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Exploring the Mechanism of Indigo Naturalis in the Treatment of Ulcerative Colitis Based on TLR4/MyD88/NF-κB Signaling Pathway and Gut Microbiota [PDF]
Frontiers in Pharmacology, 2021 Background: Clinical trials have proven that indigo naturalis is a candidate drug for treating ulcerative colitis (UC), but its therapeutic mechanism is still unclear.Purpose: This study aimed to evaluate the protective effect and mechanism of indigo ...
Li Han, Chen Zhang, Le-Le Ma
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Evidence and potential mechanism of action of indigo naturalis and its active components in the treatment of psoriasis [PDF]
Annals of MedicineBackground Indigo naturalis is effective against psoriasis. Indigo, indirubin and tryptanthrin, the main active components of indigo naturalis, have anti-inflammatory properties.Objective To evaluate the efficacy and safety of indigo naturalis and its ...
Linge Li, Xiaoce Cai, Naixuan Lin
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Indigo Naturalis Alleviates Dextran Sulfate Sodium-Induced Colitis in Rats via Altering Gut Microbiota [PDF]
Frontiers in Microbiology, 2020 Ulcerative colitis is a gastrointestinal disorder intricately associated with intestinal dysbiosis, but effective treatments are currently limited. Indigo naturalis, a traditional Chinese medicine derived from indigo plants, has been widely used in the ...
Yi Guo, Xiang Tan, Rongjie Cheng
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Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virus [PDF]
Chinese Medicine, 2020 Background Infections induced by influenza viruses, as well as coronavirus disease 19 (COVID-19) pandemic induced by severe acute respiratory coronavirus 2 (SARS-CoV-2) led to acute lung injury (ALI) and multi organ failure, during which traditional ...
Peng Tu +7 more
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A Comprehensive Review of the Chemistry, Pharmacokinetics, Pharmacology, Clinical Applications, Adverse Events, and Quality Control of Indigo Naturalis [PDF]
Frontiers in Pharmacology, 2021 Indigo naturalis (IN), which is derived from indigo plants such as Strobilanthes cusia (Nees) Kuntze, Persicaria tinctoria (Aiton) Spach, and Isatis tinctoria L., has been traditionally used in the treatment of hemoptysis, epistaxis, chest pain, aphtha ...
Fu Chaomei
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Acute pancreatitis associated with indigo naturalis in pediatric severe Crohn’s disease [PDF]
Intestinal Research, 2019 The incidence of inflammatory bowel disease (IBD) is rapidly increasing worldwide. Indigo naturalis is known to have an antiinflammatory effect. Indigo naturalis has been traditionally used in the treatment of IBD in China and Japan.
Hyeon-A Kim +4 more
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The mechanism of indigo naturalis and its active ingredients against ulcerative colitis [PDF]
Scientific ReportsIndigo Naturalis (IN), utilized for thousands of years in China, is known for its effects in clearing heat, removing toxins, and alleviating diarrhea. Studies indicate that IN possesses anti-ulcerative colitis (UC) effects.
Ke-Yu Ma +6 more
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Ischemic colitis induced by indigo naturalis in a patient with ulcerative colitis: a case report [PDF]
BMC Gastroenterology, 2020 Background Indigo naturalis is a Chinese herbal medicine that has currently been used to treat various inflammatory diseases, including ulcerative colitis.
Byungha Cho +5 more
doaj +5 more sources