Exploration of the effect and mechanism of indirubin on infectious bovine rhinotracheitis virus based on network pharmacology [PDF]
BMC Veterinary ResearchBackground Our team’s previous research indicates that infectious bovine rhinotracheitis virus (IBRV) induces mitochondrial damage in bovine kidney cells (MDBK). Indirubin, a bisindole alkaloid, can alleviate mitochondrial damage.
Xuelian Ma +9 more
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Indirubin attenuates sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages [PDF]
Frontiers in PharmacologyBackgroundIsatidis Folium, a botanical drug widely used in traditional medicine, is known for its anti-inflammatory properties, including heat-clearing, detoxifying, and blood-cooling effects. Although its potential in sepsis treatment has been suggested,
Yancen Li +9 more
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Indirubin alleviates CCl4-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Liver fibrosis is a common liver disease caused by chronic liver damage. However, there are currently no approved drugs available to treat it. Therefore, the therapeutic effect of indirubin on liver fibrosis was evaluated.
Xiaoying Li, Yuanzhi Yao, Lin Wei
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Indirubin Increases CD4+CD25+Foxp3+ Regulatory T Cells to Prevent Immune Thrombocytopenia in Mice. [PDF]
PLoS ONE, 2015 Indirubin, a traditional Chinese medicine, is used to treat autoimmune diseases in clinics. However, the effects of indirubin on the immunosuppressive CD4+CD25+Foxp3+ regulatory T cells (Treg) have not been addressed.
Aijun Zhang +4 more
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Applied Sciences, 2021 Indigo naturalis, which is extracted from the leaves and branches of Baphicacanthus cusia (Nees) Bremek, has traditionally been used to treat psoriasis.
Ly Thi Huong Nguyen +4 more
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Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment [PDF]
Journal of Biological EngineeringNanofibrous scaffolds have been established as capable platforms for localized drug delivery systems of skin cancer management. Our study aimed to develop an electrospun nanofibrous scaffold loaded with indirubin, a naturally occurring bisindole alkaloid
Sajad Rahimi +4 more
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Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy [PDF]
Scientific ReportsThis study investigated the effects of indirubin on autophagy and apoptosis in cervical cancer models, with a focus on elucidating the underlying molecular mechanisms.
Xiuchao Xie +7 more
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Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation [PDF]
Advanced ScienceMany plant‐derived bioactive molecules with low solubility and permeability can cause hepatocyte injury. However, the mechanism by which they induce hepatic damage without passive diffusion into the hepatic circulatory system remains unclear.
Yiqi Xu +9 more
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The mechanism of indigo naturalis and its active ingredients against ulcerative colitis [PDF]
Scientific ReportsIndigo Naturalis (IN), utilized for thousands of years in China, is known for its effects in clearing heat, removing toxins, and alleviating diarrhea. Studies indicate that IN possesses anti-ulcerative colitis (UC) effects.
Ke-Yu Ma +6 more
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Combining Network Pharmacology, Molecular Docking and Experimental Validation to Explore the Effects and Mechanisms of Indirubin on Acute Lymphoblastic Leukemia [PDF]
Drug Design, Development and TherapyLu Jin,1,2 Yunshuang Guan,3 Xue Li,3,4 Mingyue Wang,2 Ying Shen,1,2 Nianxue Wang,3 Zhixu He1,2,5 1Department of Pediatrics, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2Department of Pediatric ...
Jin L +6 more
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