Results 21 to 30 of about 3,427 (196)

Mechanically Interlocked Indigo Photoswitches. [PDF]

Angew Chem Int Ed Engl
By incorporating indigo photoswitches into the axle of a rotaxane, which features a hydrogen bonding macrocycle, we demonstrate improvement in activation wavelength, photostationary states and thermal reversion, an effect that is governed by topologically constrained supramolecular interactions.
Wilmshurst AM, Jo T, Kerridge RL, Sangolkar AA, Ling Z, Buchanan A, Wells N, Ben-Tal Y, Crespi S, Williams GT.   +9 more
europepmc   +3 more sources

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Frontiers in Immunology, 2022
ObjectiveTo investigate the efficacy of indirubin combined with human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of psoriatic lesions in BALB/c mice and to explore the related mechanism of indirubin in the treatment of psoriasis ...
XiaoJuan Lu, Hao Wang, Hongwei Wang, Fan Xie, Cuibao Jiang, Danpeng Shen, Hongpeng Zhang, Jie Yang, Youshu Lin   +8 more
doaj   +1 more source

Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1

BMC Complementary Medicine and Therapies, 2020
Background Psoriasis is a common inflammatory skin disease. Abnormal proliferation of keratinocytes is one of the psoriatic histopathological features.
Shou Gang Liu, Guang Pu Luo, Yong Bin Qu, Yong Feng Chen   +3 more
doaj   +1 more source

Exploring the Mechanism of Indigo Naturalis in the Treatment of Ulcerative Colitis Based on TLR4/MyD88/NF-κB Signaling Pathway and Gut Microbiota

Frontiers in Pharmacology, 2021
Background: Clinical trials have proven that indigo naturalis is a candidate drug for treating ulcerative colitis (UC), but its therapeutic mechanism is still unclear.Purpose: This study aimed to evaluate the protective effect and mechanism of indigo ...
Qi-yue Yang, Le-le Ma, Chen Zhang, Jun-zhi Lin, Li Han, Ya-nan He, Chun-guang Xie   +6 more
doaj   +1 more source

High Sensitivity Analysis of Indirubin by Silylation Using GC/MS [PDF]

, 2003
After adding the silylating agents N, O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) or N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide (MTBSTFA) to the indirubin solution and leaving for 1 hr at 60°C, the color remained red. Indirubin could be
Miyairi, Shinichi, Sekizawa, Jun, Ishibashi, Yasuhiro, Kohra, Shinya, Yamashita, Kohei, Inudo, Makiko, Takao, Yuji, Tominaga, Nobuaki, Nagae, Masaki, Arizono, Koji   +9 more
core   +1 more source

Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy

AMB Express, 2020
Glioma causes significant mortality across the world and the most aggressive type of brain cancer. The incidence of glioma is believed to increase in the next few decades and hence more efficient treatment strategies need to be developed for management ...
Zhaohui Li, Han Wang, Jun Wei, Liang Han, Zhigang Guo   +4 more
doaj   +1 more source

Effect of indirubin on the expression of proinflammatory cytokines in keratinocytes

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To investigate the effect of indirubin on the expression of proinflammatory cytokines in HaCaT cells, and to elucidate the mechanisms of Diqing ointment in the treatment of psoriasis.
Qingwen LI, Shougang LIU, Jingxia LIN, Yongfeng CHEN   +3 more
doaj   +1 more source

Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer

Molecules, 2022
Aryl hydrocarbon receptor (AhR) activation by environmental agents and microbial metabolites is potentially implicated in a series of skin diseases. Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ...
Panagiotis Kallimanis, Ioanna Chinou, Angeliki Panagiotopoulou, Anatoly A. Soshilov, Guochun He, Michael S. Denison, Prokopios Magiatis   +6 more
doaj   +1 more source

Early ADMET profiling of anti-inflammatory alkaloids using validated LC-MS/MS methods [PDF]

, 2016
Natural products provide an important and unique source of new lead compounds for drug discovery. Approximately 50% of all new chemical entities are inspired by nature.
Jähne, Evelyn
core   +1 more source

Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin

Bioresources and Bioprocessing, 2022
Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient production of indirubin in Escherichia ...
Bing-Yao Sun, Hua-Lu Sui, Zi-Wei Liu, Xin-Yi Tao, Bei Gao, Ming Zhao, Yu-Shu Ma, Jian Zhao, Min Liu, Feng-Qing Wang, Dong-Zhi Wei   +10 more
doaj   +1 more source