Results 11 to 20 of about 3,427 (196)

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases [PDF]

Evidence-Based Complementary and Alternative Medicine, 2015
Indirubin is the active component of Danggui Longhui Wan, a traditional Chinese medicine formulation. The encouraging clinical results from the 1980s obtained in chronic myelocytic leukemia patients treated with indirubin stimulated numerous studies on this compound.
Blazevic, Tina, Heiss, Elke H, Atanasov, Atanas G, Breuss, Johannes M, Dirsch, Verena M, Uhrin, Pavel   +5 more
core   +5 more sources

Indirubin-3′-monoxime suppresses amyloid-beta- induced apoptosis by inhibiting tau hyperphosphorylation

Neural Regeneration Research, 2016
Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer′s disease.
Shu-gang Zhang, Xiao-shan Wang, Ying-dong Zhang, Qing Di, Jing-ping Shi, Min Qian, Li-gang Xu, Xing-jian Lin, Jie Lu   +8 more
doaj   +2 more sources

Indirubin may be involved in the pathogenesis of psoriasis by targeting MAPK14

Pifu-xingbing zhenliaoxue zazhi
Objective To investigate the target of indirubin in psoriasis, and to elucidate the possible effect of indirubin on psoriasis through MAPK14. Methods The GSE30999 and GSE78097 psoriasis datasets downloaded from the Gene Expression Omnibus (GEO) database ...
Shougang LIU, Fanghua LIU, Yongfeng CHEN
doaj   +2 more sources

Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway

Drug Design, Development and Therapy, 2018
Lihong Chen, Jinhua Wang, Jianbo Wu, Qiaomei Zheng, Jifen Hu Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China Background: Indirubin is the active component of Danggui Longhui Wan, a ...
Chen L, Wang J, Wu J, Zheng Q, Hu J
doaj   +1 more source

A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog

Pharmaceutics, 2020
Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia.
Seol Hwa Seo, Eunhwan Kim, Yechan Joo, Juseung Lee, Kyung Taek Oh, Sung-Joo Hwang, Kang-Yell Choi   +6 more
doaj   +2 more sources

Indirubin Treatment of Lipopolysaccharide-Induced Mastitis in a Mouse Model and Activity in Mouse Mammary Epithelial Cells

Mediators of Inflammation, 2017
Indirubin is a Chinese medicine extracted from indigo and known to be effective for treating chronic myelogenous leukemia, neoplasia, and inflammatory disease.
Jin-lun Lai, Yu-hui Liu, Yong-chong Peng, Pan Ge, Chen-fei He, Chang Liu, Ying-yu Chen, Ai-zhen Guo, Chang-min Hu   +8 more
doaj   +2 more sources

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system [PDF]

International Journal of Nanomedicine, 2012
Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaBackground: Indirubin, isolated from the leaves of the Chinese herb Isatis
Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP
doaj   +1 more source

A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin N-Glycosides and Indirubin-3′-Monoxime in Plasma and Cell Culture Medium

Molecules, 2022
Indirubin was identified as an active component of Danggui Longhui Wan, an herbal mixture used in traditional Chinese medicine, and showed anticancer activity in clinical trials in patients with chronic leukemia.
Alica Fischle, Rico Schwarz, Franziska Wendt, Marcel Kordt, Robert Ramer, Lars Boeckmann, Martin Hein, Peter Langer, Steffen Emmert, Brigitte Vollmar, Burkhard Hinz   +10 more
doaj   +2 more sources

Advances in microbial biosynthesis of indirubin. [PDF]

Chin Herb Med
Indirubin (IND), a bisindole alkaloid with remarkable pharmacological activities, has attracted significant attention in the pharmaceutical field due to its antileukemic, anti-inflammatory, and immunomodulatory properties. Currently, indirubin primarily relies on plant extraction and chemical synthesis, which are hindered by complex processes, low ...
Li K, Xiang F, Yang X, Liu M, Long R, Han L, Yang M, Zhang D, He Y.   +8 more
europepmc   +3 more sources

All-Red-Light Photoswitching of Indirubin Controlled by Supramolecular Interactions [PDF]

, 2021
Red light responsiveness of photoswitches is a highly desired property for many important application areas such as biology or material sciences. The main approach to elicit this property uses strategic substitution of long known photoswitch motives such
Peter, Mayer, Stefan, Thumser, Henry, Dube, Nadine, Hoffmann, Laura, Köttner   +4 more
core   +2 more sources