Results 131 to 140 of about 173,215 (241)

Efficacy and Safety of Anal High‐Grade Squamous Intraepithelial Lesion Treatment Modalities: A Systematic Review

open access: yesANZ Journal of Surgery, Volume 96, Issue 9, Page 2339-2352, September 2026.
ABSTRACT Background There is compelling evidence that treating high‐grade squamous intraepithelial lesions (HSIL), the anal squamous cell cancer (ASCC) precursor, reduces the risk of developing ASCC. Using high‐resolution anoscopy (HRA), surgical excision, ablative and topical therapies are widely used to treat HSIL.
Matthew Joseph Marino   +5 more
wiley   +1 more source

Assessment of Red Dichromatic Imaging with Indigo Carmine for Identifying Deep Submucosal Invasion in Colorectal Tumors: A Pilot Study. [PDF]

open access: yesDiagnostics (Basel)
Futakuchi T   +8 more
europepmc   +1 more source

Diagnostic Performance and Reproducibility of Chromoendoscopic Classification (FOCUS Classification: Flat‐Type Dysplasia Optical Assessment by Chromoendoscopy in Ulcerative ColitiS) for Flat‐Type Dysplasia in Ulcerative Colitis–Associated Neoplasia

open access: yesDigestive Endoscopy, Volume 38, Issue 9, September 2026.
The FOCUS classification provides simple chromoendoscopic risk stratification for flat‐type dysplasia in ulcerative colitis. ABSTRACT Objectives Ulcerative colitis‐associated neoplasia (UCAN) often presents as flat‐type dysplasia that is difficult to characterize endoscopically.
Kaoru Takabayashi   +23 more
wiley   +1 more source

Bidirectional EEG Neurofeedback of Sensorimotor Beta Oscillations Reveals Asymmetric Modulation and Strategy‐Dependent Learning

open access: yesEuropean Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Healthy participants performed EEG‐based neurofeedback (ENF) to modulate sensorimotor beta activity. Most successfully decreased beta, few increased it and learning varied by strategy, engagement and fatigue. Early ENF performance reflects effortful, strategy‐driven control rather than stable neurophysiological change, challenging binary ‘responder ...
Krithika Anil   +4 more
wiley   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

open access: yesThe FEBS Journal, Volume 293, Issue 17, Page 5255-5281, September 2026.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero   +8 more
wiley   +1 more source

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