Results 181 to 190 of about 777,638 (289)

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

A Prospective Comparative Study to Assess the Accuracy of Energy Expenditures Calculated by Bioimpedance Analysis and Indirect Calorimetry. [PDF]

Cureus
Saseedharan S, Bhalerao A, Badve K.
europepmc   +1 more source

Biocatalytic synthesis of S‐adenosyl‐l‐methionine analogues for allosteric activation of cystathionine‐β‐synthase

The FEBS Journal, EarlyView.
Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal, Žaneta Zajacová, Rick Oerlemans, Jana Havlikova, Gabriel Zorkócy, Lukáš Kerti, Katarína Sujová, Adrian Lengyel, Zoë van der Gun, Christina Yoseif, Adrianus Cornelis van der Graaf, Guido Krenning, Ján Kyselovič, Vladimír Frecer, Matthew R. Groves, Zdenko Levarski, André Heeres, Rob H. Henning, Leo E. Deelman   +18 more
wiley   +1 more source

Evaluation of a thigh-worn accelerometer for detecting leg fidgeting and estimating its energetic cost via indirect calorimetry. [PDF]

Sci Rep
Narayanan A, Wood M, Duncan S, Stewart T.   +3 more
europepmc   +1 more source

Gastrojejunocolic Fistula Following Subtotal Stomach-preserving Pancreaticoduodenectomy with Undernutrition, Efficiently Managed via Indirect Calorimetry. [PDF]

Intern Med
Nakamura R, Yanagimachi M, Abe T, Terada A, Nishiya Y, Sato E, Nagase H, Ishido K, Hakamada K, Fujita Y.   +9 more
europepmc   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling, Lena Marth, Katja Sandkühler, Anna Stockbauer, Elisabeth Wlasich, Alexander Jäck, Olivia Wagemann, Julia Kustermann, Steffen Halbgebauer, Hayrettin Tumani, Günter Höglinger, Johannes Levin   +11 more
wiley   +1 more source

Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients. [PDF]

Crit Care
von Renesse J, von Kessel MKF, Oehme F, Kirchberg J, Kalandarishvili M, Nebelung H, Merboth F, Mirtschink P, Weitz J, Distler M, Held HC, Kühn JP, Meisterfeld R.   +12 more
europepmc   +1 more source

Feeding Laboratory Mice: Comparing a Standard Versus a Purified Diet – Marked Effects on Digestive Physiology

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Diet composition and processing have a major impact on its utilisation by the animal, as is known from farm and pet animal species. This includes effects on energy and nutrient digestibility, the intermediary metabolism, and the intestinal microbiome, with all the resulting impacts. For laboratory animals, data is scarce on influencing factors
L. F. Böswald, A. Zeyner, M. M. Santo, M. Wensch‐Dorendorf, A. Sünder, B. Popper, W. Siegert   +6 more
wiley   +1 more source

Shiny-Calorie: a context-aware application for indirect calorimetry data analysis and visualization using R. [PDF]

Bioinform Adv
Grein S, Elschner T, Kardinal R, Bruder J, Strohmeyer A, Gunasekaran K, Witt J, Hermannsdóttir H, Behrens J, U-Din M, Yu J, Heldmaier G, Schreiber R, Rozman J, Heine M, Scheja L, Worthmann A, Heeren J, Wachten D, Wilhelm-Jüngling K, Pfeifer A, Hasenauer J, Klingenspor M.   +22 more
europepmc   +1 more source

Resynchronisation of the Biological Clock Using Exposure to Low Oxygen Levels in Humans: An Exploratory Study

Journal of Sleep Research, EarlyView.
ABSTRACT Exposure to reduced oxygen levels occurs in several real‐world contexts, such as during air travel or altitude exposure, and emerging evidence suggests that hypoxia may interact with molecular pathways involved in circadian regulation. This exploratory study investigated the effects of normobaric hypoxia on circadian phase shifting in humans ...
Renée Morin, Geneviève Forest, Kim Isabelle‐Nolet, Vincent Bourgon, Félix‐Gabriel Duval, Jean‐François Mauger, Pascal Imbeault   +6 more
wiley   +1 more source