Results 191 to 200 of about 745,863 (244)

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

open access: yesThe FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan   +8 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

open access: yesThe FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa   +1 more
wiley   +1 more source

Bio‐active designed peptide for hair keratin strengthening

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Bioactive tripeptides through in silico screening revealed KCV (Tripeptide‐132) as the most promising keratin‐targeting candidate. Experimental studies confirmed its superior hair‐strengthening performance with 44% tensile strength enhancement, 50% breakage reduction, improved surface integrity and fibre penetration.
Chan‐Su Rha   +6 more
wiley   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

open access: yesJournal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling   +11 more
wiley   +1 more source

Feeding Laboratory Mice: Comparing a Standard Versus a Purified Diet – Marked Effects on Digestive Physiology

open access: yesJournal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Diet composition and processing have a major impact on its utilisation by the animal, as is known from farm and pet animal species. This includes effects on energy and nutrient digestibility, the intermediary metabolism, and the intestinal microbiome, with all the resulting impacts. For laboratory animals, data is scarce on influencing factors
L. F. Böswald   +6 more
wiley   +1 more source

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