Results 91 to 100 of about 2,085,056 (273)

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Diagnostic performance of ELISA kits and expanded antigen panels for hemagglutination inhibition assays in pig herds enzootically infected with porcine Influenza A viruses

Porcine Health Management
Background A combined approach using both indirect and direct detection methods can improve the diagnostic efficiency of swine Influenza A virus (swIAV) infections. Despite its importance, limited research has been conducted on the diagnostic performance
J. Stadler, K. Grau, K. Lillie-Jaschniski, S. Pesch, A. Graaf-Rau, T. Harder, S. Zoels, R. Fux, M. Ritzmann, M. Eddicks   +9 more
doaj   +1 more source

Characterization of a novel B-cell epitope in the structural protein of goose astrovirus 1 and its application in serological detection

Poultry Science
Goose astrovirus 1 (GAstV-1) is an emerging pathogen responsible for gosling gout and has caused substantial economic losses in the goose industry, particularly during frequent co-infections with goose astrovirus 2 (GAstV-2) that exacerbate pathogenicity.
Anping Wang, Li Liu, Qingkang Zhou, Xiaolu Zhang, Zhi Wu, Shanyuan Zhu   +5 more
doaj   +1 more source

Detection of Candida albicans Sap2 in cancer patient serum samples by an indirect competitive enzyme-linked immunosorbent assay for the diagnosis of candidiasis

Indian Journal of Pathology and Microbiology, 2013
Background: The secreted aspartyl proteinases 2 (Sap2) of Candida albicans (C. albicans) is a potential marker of candididasis. It is a virulence factor associated with adherence and tissue invasion.
Yicun Wang, Xiang Gao, J U Zhi gang, Jingyuan Liu, Shuai Dong, Li Wang   +5 more
doaj   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Preparation of monoclonal antibody against chloramphenicol and establishment of direct competitive ELISA for determination of chloramphenicol

浙江大学学报. 农业与生命科学版, 2010
Through immunization of BALB/c mice with synthesized CAP-ovalbumin (CAP-OVA), a hybridoma cell line, the 4C9 which could produce monoclonal antibody against chloramphenicol (CAP) and propagate stably, was established.
CHEN Zheng-xian, SHI Man-ling, LI Yin-lai, YE Xing-qian, SHEN Li-rong   +4 more
doaj   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Co-infection of brucellosis and tuberculosis in slaughtered cattle in Ibadan, Nigeria: a case report [PDF]

Veterinaria Italiana, 2008
The authors present a case report on co-infection of brucellosis and tuberculosis in cattle slaughtered at the Bodija abattoir in Ibadan, Nigeria. Out of 32 animals that were seropositive for brucellosis using the Rose Bengal test, indirect enzyme-linked
Judy A. Stack, Hezekiah K. Adesokan, Simeon I.B. Cadmus   +2 more
doaj  

Development of an ELISA and Immunochromatographic Strip for Highly Sensitive Detection of Microcystin-LR

Sensors, 2014
A monoclonal antibody for microcystin–leucine–arginine (MC-LR) was produced by cell fusion. The immunogen was synthesized in two steps. First, ovalbumin/ bovine serum albumin was conjugated with 6-acetylthiohexanoic acid using a carbodiimide EDC (1 ...
Liqiang Liu, Changrui Xing, Huijuan Yan, Hua Kuang, Chuanlai Xu   +4 more
doaj   +1 more source