Results 111 to 120 of about 2,085,056 (273)

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Indirect competitive enzyme-linked immunosorbent assay (ELISA) for the determination of mammalian gelatin in pharmaceutical capsules

, 2018
Gelatin is derived from partial hydrolysis of type I collagen (connective tissues such as skin, bone, tendon, and ligament), which is commonly obtained from mammalian sources (porcine and bovine).
Hamid, Muhajir, Tukiran, Nur Azira, Amin Ismail, Muhajir Hamid, Ismail, Amin, Mustafa, Shuhaimi, Nur Azira Tukiran, Shuhaimi Mustafa   +7 more
core   +1 more source

Partners or passengers? Revisiting the association between diatoms and aquatic animals

Biological Reviews, EarlyView.
ABSTRACT Numerous studies have revealed the importance of research on the communities capable of colonizing animal surfaces (epibionts) and the animals on which they live (basibionts). Very few studies have considered epizoic diatoms, and there are gaps and biases in our knowledge, including the choice of basibionts, the methods used, and the habitats ...
Gianluca Vacca, Elisa Falasco, Francesca Bona   +2 more
wiley   +1 more source

Development of indirect Competitive ELISA for the detection of dibutyl phthalate in food

, 2019
In this study, 4-aminophthalic acid was used to synthesize hapten Dibutyl 4-aminophthalate by esterification reaction, and the synthesized hapten was coupled with keyhole limpet hemocyanin (KLH) by diazotization reaction to prepare the immune antigen and
Shuna, SHANG, Qiuxia, ZHAO, Lulu, WANG, Wei, SHENG, Shuo, WANG   +4 more
core   +1 more source

Stock Market Reactions to Climate Risk Events: A Systematic Literature Review and Research Agenda

Business Strategy and the Environment, EarlyView.
ABSTRACT As global warming intensifies, climate risks' impact on firm value has become a critical concern for academia and investors. This systematic literature review analyzes 50 event studies in this research field, classifying them by climate risk type.
Mario Schuster, Rainer Lueg
wiley   +1 more source

Establishment of a high-sensitivity indirect competitive ELISA for florfenicol in chicken meat and egg

The aim was to develop a highly sensitive indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) method for detecting florfenicol (FF) in chicken meat and eggs.
Y. Xing, Cai, W., Hu, X., Y. Sun, Ge, M., Xing, Y., X. Hu, Y. Wang, Sun, Y., Wang, Y., M. Ge, W. Cai   +11 more
core   +1 more source

Board Gender Diversity and Eco‐Innovation: The Moderating Role of Organisational Environmental Orientation

Business Strategy and the Environment, EarlyView.
ABSTRACT Corporate sustainability has become a strategic priority in response to growing regulatory, social and environmental pressures, placing greater emphasis on governance structures, such as board composition, that shape the incorporation of ethical and sustainable values into corporate decision‐making.
Isabel‐María García‐Sánchez, Germán López‐Pérez, Elisabeth Zafra‐Gómez, José L. Zafra‐Gómez   +3 more
wiley   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

ELISA

, 2015
Raw data form TGF-b activation performed by ELISA ...
Tania C. Araujo-Jorge (3322635), Antônio S. Gonçalves (3322632), Mariana C. Waghabi (158752), Leila Mendonça-Lima (319640), Patrícia M. Ferrão (319637), Luciana R. Garzoni (367277), Jean Jacques Feige (734539), Sabine Bailly (158749), Ana Paula Lima (734538), Wim M. Degrave (158743), Claudia M. d'Avila-Levy (225684)   +10 more
core   +1 more source