Results 141 to 150 of about 2,686,565 (303)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Mediation analyses for the effect of antibodies in vaccination
Journal of Causal InferenceWe review standard mediation assumptions as they apply to identifying antibody effects in a randomized vaccine trial and propose new study designs to allow the identification of an estimand that was previously unidentifiable. For these mediation analyses,
Fay Michael P., Follmann Dean A.
doaj +1 more source
Research on Lightning Coupling Rule of the Equipment Port of Maglev Train
机车电传动, 2020 Compared with the traditional wheel-rail train, the maglev train is more vulnerable to lightning strikes due to the lack of contact net protection. In severe cases, it will cause damage to the vehicle-mounted equipment and affect the safety of the train.
Jianying LIANG, Shi XIAO, Fujie JIANG
doaj
Stronger Response to the Aerosol Indirect Effect Due To Cooling in Remote Regions. [PDF]
Geophys Res Lett, 2022 Huusko L, Modak A, Mauritsen T.
europepmc +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
The Impact of Cyberbullying Victimization on Academic Satisfaction among Sexual Minority College Students: The Indirect Effect of Flourishing. [PDF]
Int J Environ Res Public Health, 2023 Lee JM +4 more
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
The indirect effect of positive aspects of caregiving on the relationship between cognitive decline and dementia caregiver burden. [PDF]
Psychogeriatrics, 2023 Cousins E +4 more
europepmc +1 more source
Aging and Cancer, EarlyView.This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source