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On the Interpretation and Use of Mediation: Multiple Perspectives on Mediation Analysis

open access: yesFrontiers in Psychology, 2017
Mediation analysis has become a very popular approach in psychology, and it is one that is associated with multiple perspectives that are often at odds, often implicitly.
Robert Agler   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Path coefficient analysis studies in rice (Oryza sativa L.) for quantitative and qualitative traits

open access: yesElectronic Journal of Plant Breeding, 2019
Path coefficient studies were carried out for yield and quality traits in 74 rice genotypes involving hybrids and their parental lines. Grains per panicle, productive tillers per plant and amylose content were significant and positive direct effects on ...
R. Arulmozhi and A. Muthuswamy
doaj   +1 more source

The European Court of Justice case of Elgafaji: the interaction between EU law and international humanitarian law [PDF]

open access: yesBaltic Region, 2011
This article focuses on the increasing influence of international court rulings on the development of new concepts within international law, in particular, the concept of subsidiary protection to persons who fall outside the scope of the 1951 Refugee ...
Ispolinov Alexei
doaj   +1 more source

Direct and Indirect Effects in a Logit Model [PDF]

open access: yesThe Stata Journal: Promoting communications on statistics and Stata, 2010
In this article, I discuss a method by Erikson et al. (2005, Proceedings of the National Academy of Science 102: 9730–9733) for decomposing a total effect in a logit model into direct and indirect effects. Moreover, I extend this method in three ways. First, in the original method the variable through which the indirect effect occurs is assumed to be ...
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

A computational description of simple mediation analysis [PDF]

open access: yesTutorials in Quantitative Methods for Psychology, 2018
Simple mediation analysis is an increasingly popular statistical analysis in psychology and in other social sciences. However, there is very few detailed account of the computations within the model.
Caron, Pier-Olivier, Valois, Philippe
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Effect of three environments on the efficiency of indirect selection in Eragrostis curvula (lovegrass) genotypes [PDF]

open access: yes, 2003
A significant genotype environment interaction can limit gains in selecting superior genotypes since the best genotype in one locality may not be the best one in another locality. The efficiency of indirect selection is related to the heritability of the
Di Renzo, Miguel Angel   +5 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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