Results 201 to 210 of about 6,947,712 (267)

Recent advances in volumetric super-resolution imaging through computational adaptive optics. [PDF]

Mol Brain
Park S, Jeong S, Yoo C, Kim M.
europepmc   +1 more source

Next Generation Antimicrobial Coatings for High Touch Surfaces: Application, Benefits, Risks, Environmental Impacts and Sustainability Aspects

Advanced Science, EarlyView.
Antimicrobial coatings for high touch surfaces promise infection control but are too often validated only in the lab. This review shows that active‐agent release governs both human toxicity and environmental impact and argues that durability and real‐world performance must be primary design criteria, placing a safe‐and‐sustainable‐by‐design framework ...
Nurshen Mutlu, Peter Askew, Alexander J. Cunliffe, Damjana Drobne, Stefan Fischer, Gillian Iredale, Pascal Kock, Veno Kononenko, Susanne Kurz, Patrick Lichtner, Abby Marchant, Philipp Meier, James Redfern, Giacomo Reina, Simone Schulte, Juliane Spohn, Merve Tunali, Peter Wick, Nihal Engin Vrana, Bernd Nowack   +19 more
wiley   +1 more source

Deep Actor-Critic Reinforcement Learning (DA-CRL) based multi-objective optimal control of solar PV integrated UPQC for power quality enhancement in smart distribution networks. [PDF]

Sci Rep
Bindu EH, Prasanna PBG, Krishna D, Goud BS, Balachandran PK.   +4 more
europepmc   +1 more source

Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell‐Mediated Exosomal Trafficking

Advanced Science, EarlyView.
MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin, Qianwen Li, Duo Liu, Mingzhao Li, Han Zhang, Liujing Chen, Yan Yu, Jiuhui Jiang, Chun Xu, Ruili Yang   +9 more
wiley   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Sterile inflammation in LHON: mitochondrial stress, innate immune signaling, and implications for AAV gene therapy. [PDF]

Front Immunol
Zhang X, Chang A, Liu Y, Yu H.
europepmc   +1 more source

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

Integrating Low-Cost xTB Electronic Priors for Predicting Electronic and Excited-State Properties of Organic Conjugated Molecules. [PDF]

Chemphyschem
Zeng M, Huai L, Liu T, Liu Y, Jiang X.
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source