Results 211 to 220 of about 6,947,712 (267)

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

open access: yesAdvanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni   +14 more
wiley   +1 more source

An Iontronic Bimodal Afferent Nerve for Cross‐Modal Neuromorphic Fusion and Robotic Sorting

open access: yesAdvanced Science, EarlyView.
A flexible iontronic pressure–temperature sensor is integrated with pulse encoding and a multi‐gate SnO2 nanowire synaptic transistor to create a near‐sensor neuromorphic platform. Pressure and temperature cues are encoded, temporally integrated, and fused for accurate multimodal object recognition and robotic sorting, establishing a compact pathway ...
Mengkang Deng   +10 more
wiley   +1 more source

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu   +8 more
wiley   +1 more source

Hierarchical Organization of Biomaterials in the Formation of Photonic Nanostructures

open access: yesAdvanced Science, EarlyView.
Natural organisms create vibrant structural colors through precisely organized nanostructures formed under mild biological conditions. This review explores how cellulose, chitin, corneous beta‐protein, and melanin form complex nanostructures across molecular, mesoscale, and tissue levels.
Sangyeop Kim   +5 more
wiley   +1 more source

SensEnhance: A Genetic Circuit for Converting Endogenous Mammalian Gene Signals Into High‐Dynamic‐Range Genetic Readouts

open access: yesAdvanced Science, EarlyView.
Here, we present SensEnhance, a modular genetic circuit that converts leaky, low‐dynamic‐range promoter signals into tightly controlled, high‐dynamic‐range outputs. Applied to mechanosensing and IL‐6‐responsive promoters, SensEnhance increases fold changes from 2.6‐ and 2.5‐fold in promoter‐only configurations to over 20‐ and 14‐fold, respectively ...
Miguel Baños   +4 more
wiley   +1 more source

The perfect carbon TOCSY (iPE TOCSY) facilitates assignment of large biomolecules. [PDF]

open access: yesJ Biomol NMR
Löbbert A   +4 more
europepmc   +1 more source

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