Results 41 to 50 of about 39,062 (298)

DISCURSO REPRODUCIDO Y LA EXPRESIÓN DE LA INTENCIONALIDAD DE PERSONAJES. UNA HISTORIA RECONTADA POR NIÑOS Y JÓVENES EN EDAD ESCOLAR [PDF]

open access: yesLingüística, 2019
Este estudio analiza el discurso reproducido, de habla y pensamiento, y su relación con la expresión de intenciones y deseos de los personajes de un cuento recontado por niños y jóvenes mexicanos.
Luisa Josefina Alarcón Neve
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

FUNGSI DAN PERAN TINDAK TUTUR IMPERATIF TIDAK LANGSUNG DALAM BAHASA JEPANG

open access: yesLingua Didaktika: Jurnal Bahasa dan Pembelajaran Bahasa, 2015
By using the indirect imperative speech acts, someone can give an order to other people without making the other person feel that he/she is being ordered or demeaned. However, sometimes the other person does not understand the meaning or message conveyed
Nova Yulia
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Speech act theory, discourse structure and indirect speech [PDF]

open access: yes, 1991
Speech Act Theory is concerned with the ways in which language can be used. It originated with Austin, but was developed by Searle. The theories of Austin and Searle are described and several problem areas are identified.
Smith, Peter Wilfred Hesling
core  

The effect of genre on reporting speech: conversations and newspaper articles

open access: yesBorealis: An International Journal of Hispanic Linguistics, 2012
This study focuses on reported speech in two different genres: spoken conversation and newspaper articles. There are two basic structures that allow language users to report formerly uttered words: direct and indirect speech.
Fleur van der Houwen
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

SPEECH, THOUGHT AND WRITING REPRESENTATION MODES IN JANE AUSTENʼS NOVEL SENSE AND SENSIBILITY

open access: yesFilolog, 2020
Bakhtin’s views (1980:127-130) on the importance of studying speech representation and its interaction with authorial context incited prolific research in various disciplines.
Маја Р. Ковачевић
doaj  

Le discours rapporté à l’épreuve de la représentation de la pensée dans Night and Day de Virginia Woolf : degré de vraisemblance

open access: yesE-REA, 2019
This article aims at studying in what ways the three major types of reported speech, namely direct speech, free indirect speech and indirect speech, give a more or less lifelike representation of the characters' thought in Virginia Woolf's Night and Day,
Alexandra PEDINIELLI-FÉRON
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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