Results 51 to 60 of about 39,062 (298)

Direct and indirect effects of social dominance orientation on hate speech perpetration via empathy and moral disengagement among adolescents: A multilevel mediation model [PDF]

open access: yes, 2023
Although it is known that social dominance orientation directly affects hate speech perpetration, few studies have explored the mechanisms by which this effect takes place during adolescence.
Melisa Castellanos   +7 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Grounding, semantic motivation, and conceptual interaction in Indirect Directive Speech Acts [PDF]

open access: yes, 2002
In this paper we attempt to develop the still programmatic but insightful proposal made by Thornburg and Panther (1997) and Panther and Thornburg (1998), according to which the identification of the intended meaning (or illocutionary force) of indirect ...
Ruiz De Mendoza, F.J. [0000-0002-1200-2850]   +1 more
core   +1 more source

Plans, inference, and indirect speech acts [PDF]

open access: yesProceedings of the 17th annual meeting on Association for Computational Linguistics -, 1979
One of the central concerns of a theory of pra~atics is to explain what actions language users per fo rm by making u t t e r a n c e s . Th is concern i s a lso r e l e v a n t to the d e s i g n e r s o f c o n v e r s a t i o n a l language unde rs tand ing systems, e s p e c i a l l y those i n tended to coope ra te w i t h a user in the e x e c u t
James F. Allen, C. Raymond Perrault
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

DIRECT AND INDIRECT SPEECH IN RUSSIAN LANGUAGE

open access: yes, 2023
The article is devoted to the interpretation and description of direct and indirect speech in scientific grammars and textbooks in the modern Russian literary language.
Bozorovich, Ruziev Yarash
core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao   +7 more
wiley   +1 more source

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