Results 51 to 60 of about 2,125,910 (378)

The effect of genre on reporting speech: conversations and newspaper articles

open access: yesBorealis: An International Journal of Hispanic Linguistics, 2012
This study focuses on reported speech in two different genres: spoken conversation and newspaper articles. There are two basic structures that allow language users to report formerly uttered words: direct and indirect speech.
Fleur van der Houwen
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Le discours rapporté à l’épreuve de la représentation de la pensée dans Night and Day de Virginia Woolf : degré de vraisemblance

open access: yesE-REA, 2019
This article aims at studying in what ways the three major types of reported speech, namely direct speech, free indirect speech and indirect speech, give a more or less lifelike representation of the characters' thought in Virginia Woolf's Night and Day,
Alexandra PEDINIELLI-FÉRON
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

SPEECH, THOUGHT AND WRITING REPRESENTATION MODES IN JANE AUSTENʼS NOVEL SENSE AND SENSIBILITY

open access: yesFilolog, 2020
Bakhtin’s views (1980:127-130) on the importance of studying speech representation and its interaction with authorial context incited prolific research in various disciplines.
Маја Р. Ковачевић
doaj  

The Acquisition of Indirect Speech made by English Foreign Learners, Learning English as a Foreign Language [PDF]

open access: yes, 2016
This present study deals with the acquisition of indirect speech made by English foreign learners, especially junior and senior high school students . The objectives of this research are to identify the pattern of indirect speech from statement, command,
, Mauly Halwat Hikmat, Ph.D.   +2 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

DISCURSO REPRODUCIDO Y LA EXPRESIÓN DE LA INTENCIONALIDAD DE PERSONAJES. UNA HISTORIA RECONTADA POR NIÑOS Y JÓVENES EN EDAD ESCOLAR [PDF]

open access: yesLingüística, 2019
Este estudio analiza el discurso reproducido, de habla y pensamiento, y su relación con la expresión de intenciones y deseos de los personajes de un cuento recontado por niños y jóvenes mexicanos.
Luisa Josefina Alarcón Neve
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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