Results 31 to 40 of about 320,240 (305)
Function of the Speech acts in an allegory from Mathnavi-e Ma’navi [PDF]
زبان پژوهیIntroduction A speech act is basically an action that is realized through uttering a statement. According to speech act theory, the unit of linguistic communication is not the pronunciation of words and sentences; rather, such pronunciation is only part
Hamid Kamali Moqadam +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
An Analysis of Pembayuns Speech Acts in Sorong Serah Ceremony of Sasak Marriage: a Ritualistic Discourse Study [PDF]
, 2013 This study investigated the Pembayuns speech acts in Sorong Serah ceremony of the Sasak marriage. As such, it examined the speech events that occurred within the ritual of the ceremony.
K, S. (SEKEN) +2 more
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Daya Pragmatik Tindak Ujar Pada Wacana Rosi Di Kompas TV [PDF]
, 2018 Interpretation of every individual's speech is different. eherefore, this study will examine the effects of the speeches that expressed by Pn. There are 3 purposes in this research.
, Prof. Dr. Harun Joko Prayitno, M.Hum +1 more
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Analysing the speech act of refusing in the TV show Grey’s Anatomy [PDF]
, 2016 XXI Jornades de Foment de la Investigació de la Facultat de Ciències Humanes i Socials (Any 2016)Appropriate refusal interactions may be a difficult task for learners of English in a foreign context since they tend to apply the pragmatic rules of their ...
Nieto Bernat, Davinia María
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source