Results 31 to 40 of about 320,160 (346)

Insinuations, Indirect Speech Acts, and Deniability

open access: yesStudia Semiotyczne, 2022
DOI: https://doi.org/10.26333/sts.xxxvi2.03 Insinuations are indirect speech acts done for various reasons: a speaker S may insinuate P (i) because an insinuation is more polite, and S can save face by non-explicitly saying P (Brown, Levinson, 1987; Searle, 1975), (ii) because S can deny having insinuated P and avoid the responsibility of explicitly ...
openaire   +2 more sources

“I Hear the Cry, but I Do Not See the Tears”: Indirectness in Bribery Negotiations

open access: yesAfrican Journal of Inter-Multidisciplinary Studies
There is a relationship between crime and language, particularly crimes such as bribery, which are perpetuated through the use of language. These language-based crimes are often articulated indirectly to afford the interlocutor’s denial should such a ...
Mampoi Irene Mabena   +1 more
doaj   +7 more sources

Directive Speech Acts in The Short Film “Makr” by Hana Kazim (George Yule`s Pragmatic Study)

open access: yesTarling, 2023
This research discusses directive speech acts in the short film Makr. A directive speech act is a type of speech act that is used by the speaker to order the hearer to do something.
Febyanti Fadhliatul
doaj  

Function of the Speech acts in an allegory from Mathnavi-e Ma’navi [PDF]

open access: yesزبان پژوهی
Introduction A speech act is basically an action that is realized through uttering a statement. According to speech act theory, the unit of linguistic communication is not the pronunciation of words and sentences; rather, such pronunciation is only part
Hamid Kamali Moqadam   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

An Analysis of Pembayuns Speech Acts in Sorong Serah Ceremony of Sasak Marriage: a Ritualistic Discourse Study [PDF]

open access: yes, 2013
This study investigated the Pembayuns speech acts in Sorong Serah ceremony of the Sasak marriage. As such, it examined the speech events that occurred within the ritual of the ceremony.
K, S. (SEKEN)   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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