Results 41 to 50 of about 321,746 (339)

Directive Speech Acts in The Short Film “Makr” by Hana Kazim (George Yule`s Pragmatic Study)

open access: yesTarling, 2023
This research discusses directive speech acts in the short film Makr. A directive speech act is a type of speech act that is used by the speaker to order the hearer to do something.
Febyanti Fadhliatul
doaj  

Function of the Speech acts in an allegory from Mathnavi-e Ma’navi [PDF]

open access: yesزبان پژوهی
Introduction A speech act is basically an action that is realized through uttering a statement. According to speech act theory, the unit of linguistic communication is not the pronunciation of words and sentences; rather, such pronunciation is only part
Hamid Kamali Moqadam   +2 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

TINDAK TUTUR GURU DALAM INTERAKSI BELAJAR MENGAJAR BAHASA INDONESIA DI SMA MUHAMMADIYAH I MALANG [PDF]

open access: yes, 2006
Schools are educational institutions which are essentially aimed at changing student behavior. The process of changing behavior occurred mainly through communication.
NOR’AINI, NOR’AINI
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

“I Hear the Cry, but I Do Not See the Tears”: Indirectness in Bribery Negotiations

open access: yesAfrican Journal of Inter-Multidisciplinary Studies
There is a relationship between crime and language, particularly crimes such as bribery, which are perpetuated through the use of language. These language-based crimes are often articulated indirectly to afford the interlocutor’s denial should such a ...
Mampoi Irene Mabena   +1 more
doaj   +7 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

An Analysis of Pembayuns Speech Acts in Sorong Serah Ceremony of Sasak Marriage: a Ritualistic Discourse Study [PDF]

open access: yes, 2013
This study investigated the Pembayuns speech acts in Sorong Serah ceremony of the Sasak marriage. As such, it examined the speech events that occurred within the ritual of the ceremony.
K, S. (SEKEN)   +2 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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