Results 251 to 260 of about 13,763,316 (290)

Indirect comparisons of treatment effects in multiple sclerosis

European Journal of Clinical Pharmacology, 2012
Dear EditorWe read with interest the paper by Del Santo et al. [1] andhave one general comment and a number of specific con-cerns which we wish to express. The general commentconcerns the indirect comparison of clinical trials, whichcan be particularly misleading in multiple sclerosis (MS).Data on the placebo groups of the included trials ...
SORMANI, MARIA PIA, SIGNORI, ALESSIO
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A Comparison of Relative-Efficacy Estimate(S) Derived From Both Matching-Adjusted Indirect Comparisons and Standard Anchored Indirect Treatment Comparisons: A Review of Matching-Adjusted Indirect Comparisons

Value in Health, 2023
We present an empirical comparison of relative-efficacy estimate(s) from matching-adjusted indirect comparisons (MAICs) with estimates from corresponding standard anchored indirect treatment comparisons.A total of 80 comparisons were identified from 17 publications through a systematic rapid review.
Owen, Cassidy, Marie, Harte, Lea, Trela-Larsen, Cathal, Walsh, Arthur, White, Laura, McCullagh, Joy, Leahy   +6 more
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Use of Indirect and Mixed Treatment Comparisons for Technology Assessment

PharmacoEconomics, 2008
Indirect and mixed treatment comparison (MTC) approaches to synthesis are logical extensions of more established meta-analysis methods. They have great potential for estimating the comparative effectiveness of multiple treatments using an evidence base of trials that individually do not compare all treatment options.
Alex, Sutton, A E, Ades, Nicola, Cooper, Keith, Abrams   +3 more
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Combination of direct and indirect evidence in mixed treatment comparisons

Statistics in Medicine, 2004
AbstractMixed treatment comparison (MTC) meta‐analysis is a generalization of standard pairwise meta‐analysis for A vs B trials, to data structures that include, for example, A vs B, B vs C, and A vs C trials. There are two roles for MTC: one is to strengthen inference concerning the relative efficacy of two treatments, by including both ‘direct’ and ...
G, Lu, A E, Ades
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Simulation and Matching-Based Approaches for Indirect Comparison of Treatments

PharmacoEconomics, 2015
Estimates of the relative effects of competing treatments are rarely available from head-to-head trials. These effects must therefore be derived from indirect comparisons of results from different studies. The feasibility of comparisons relies on the network linking treatments through common comparators; the reliability of these may also be impacted ...
K Jack, Ishak, Irina, Proskorovsky, Agnes, Benedict   +2 more
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Biological treatments for moderate-to-severe psoriasis: indirect comparison

Journal of Clinical Pharmacy and Therapeutics, 2013
Psoriasis is a chronic skin disease for which there is an increasing range of treatment options. Biological agents (ustekinumab, adalimumab, infliximab and etanercept) are indicated for moderate-to-severe plaque-type psoriasis in adults who fail to respond to, have a contraindication to, or are intolerant to other systemic therapies including ...
M, Galván-Banqueri, R, Marín Gil, B, Santos Ramos, F J, Bautista Paloma   +3 more
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Network meta‐analysis for indirect treatment comparisons

Statistics in Medicine, 2002
Abstract I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta‐analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency ...
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PD66 Indirect Comparison Of Treatments For Metastatic Melanoma

International Journal of Technology Assessment in Health Care, 2018
Introduction:Vemurafenib plus cobimetinib (VC) for the treatment of metastatic melanoma was requested to be included in the National Formulary in Uruguay. The standard of care for metastatic melanoma in Uruguay is dacarbazine. There is no published head-to-head trial assessing the effects of VC versus dacarbazine.
Alicia Aleman, Daniel Pedrosa, Magdalena Irisarri, Rafael Alonso, Ana Perez Galán, Regina Guzman   +5 more
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Indirect comparisons of treatment effects: Network meta-analyses

Multiple Sclerosis Journal, 2017
Many therapeutic options are now available for patients with multiple sclerosis. While the efficacy of each drug has been assessed against placebo or, more recently, against interferon, no direct comparisons of these new therapies have been conducted in randomized clinical trials.
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Frequency of Treatment-Effect Modification Affecting Indirect Comparisons

PharmacoEconomics, 2010
A key assumption of indirect comparisons is similarity, which means that, in the face of differences in patient characteristics or study methods, there is no treatment-effect modification across sides of the indirect comparison. We therefore conducted a systematic review of MEDLINE and EMBASE from inception to November 2009 to summarize currently ...
Coory, Michael, Jordan, Susan
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