Results 141 to 150 of about 3,427 (196)

Indirubin induces apoptosis in ovarian cancer cells via the mitochondrial pathway. [PDF]

Am J Transl Res
Wang J, Chen L, Zheng Q, Chen S, Hou Z, Liu P.   +5 more
europepmc   +1 more source

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex. [PDF]

Nat Commun
Diao X, Shang Q, Guo M, Huang Y, Zhang M, Chen X, Liang Y, Sun X, Zhou F, Zhuang J, Liu SJ, Vogel CFA, Rastinejad F, Wu D.   +13 more
europepmc   +1 more source

Network Pharmacology and Experiment Verification-Based Strategy for Exploring the Mechanisms of Shuqing Granule in the Treatment of COVID-19. [PDF]

Pharmaceuticals (Basel)
Guo X, Zheng H, An Y, Song Y, Liu T, Zhou Z, Liu C, Wang G, Wang F.   +8 more
europepmc   +1 more source

Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors. [PDF]

Molecules
Kandeel MM, AbdElhameid MK, Adel M, Al-Shorbagy MY, Negmeldin AT.   +4 more
europepmc   +1 more source

Vitamin A Modulates AHR Signaling and Restricts Zika Virus Replication in Human Retinal Pigment Epithelial Cells: Insights from Molecular Modeling and Antiviral Assays. [PDF]

Pathogens
Marquez AB, Lanza Castronuovo PA, Barbieri CL, Castañeda Cataña MA, Sepúlveda CS, Alaimo A, Vera DMA, García CC.   +7 more
europepmc   +1 more source

Evaluation of Indigo Naturalis Prepared Using a Novel Method: Therapeutic Effects on Experimental Ulcerative Colitis in Mice. [PDF]

Pharmaceutics
Xu X, Lin L, Ning W, Zhou X, Ullah A, Yang H, Wu X, Diao Y.   +7 more
europepmc   +1 more source

Indirubin derivatives: a patent review (2010 – present)

Expert Opinion on Therapeutic Patents, 2015
Indirubins are bisindole alkaloids naturally occurring in indigo-bearing plants or in mollusks from the Muricidae family. They belong to the rather small family of indigoids, which has nevertheless found an extreme importance in the fields of dyes and medicinal chemistry.
Nicolas Gaboriaud-Kolar, Konstantina Vougogiannopoulou, Alexios-Léandros Skaltsounis   +2 more
exaly   +6 more sources

Pharmacological properties of indirubin and its derivatives

Biomedicine and Pharmacotherapy, 2022
Indirubin is the main bioactive component of the traditional Chinese medicine Indigo naturalis and is a bisindole alkaloid. Multiple studies have shown that indirubin exhibits good anticancer, anti-inflammatory and neuroprotective properties.The purpose of this review is to provide a summary of the pharmacological mechanisms of indirubin and its ...
Yu Lai
exaly   +3 more sources

Elucidating Cysteine-Assisted Synthesis of Indirubin by a Flavin-Containing Monooxygenase

ACS Catalysis, 2019
Indirubin is a biologically active compound found in Danggui Longhui Wan, which is a traditional Chinese medicine for chronic myelocytic leukemia. In the biosynthesis of indirubin, the formation of indigo, which is a stereoisomer of indirubin, is a major
Pyung-Gang Lee, Joonwon Kim, Wolfgang Kroutil   +2 more
exaly   +2 more sources