Results 151 to 160 of about 3,427 (196)

Synthesis and activity of novel indirubin derivatives

Chemical Biology & Drug Design, 2020
AbstractA series of indirubin derivatives hydrochloride were obtained using a convenient and mild method from indirubin. The newly synthesized compounds and their derivatives were characterized by 1H NMR, 13C NMR, and MS. Furthermore, we tested their IDO1 enzyme inhibitory activity and anti‐proliferative activities in K562 tumor cells. The experimental
Bin, Sun, Jiahao, Wang, Luohua, Liu, Longfei, Mao, Lizeng, Peng, Yuwei, Wang   +5 more
openaire   +2 more sources

Indirubin-3′-monoxime, a derivative of a Chinese anti-leukemia medicine, inhibits Notch1 signaling

Cancer Letters, 2008
Notch proteins perform a critical function in cell-fate decisions and in differentiation. In this study, we determined that indirubin-3'-monoxime reduced Notch1 signaling to a remarkable extent.
Jung-Soon Mo, Yong-Chul Kim, Eun-Jung Ann   +2 more
exaly   +2 more sources

Studies on the acetylation and NMR reassignment of indirubin derivatives

Natural Product Research, 2010
The analysis of 1D- and 2D-NMR spectroscopic data confirmed that the amino N-1' protons of indirubin and indirubin-3'-oxime resonate at a higher frequency than N-1 protons. The amino N-1' protons in both indirubin and indirubin-3'-oxime are not favourable for acetylated reaction due to their intramolecular hydrogen bonding with the amide carbonyl group.
Bui Huu Tai, Nguyen Manh Cuong
exaly   +3 more sources

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

Bioorganic and Medicinal Chemistry, 2010
Indirubins have been reported to act as potent inhibitors of protein kinases relevant to tumorigenesis and of tumor cell growth, but their development to antitumor drugs suffer from their poor water solubility. We synthesized a novel class of indirubin derivatives, indirubin-5-carboxamides, carrying amide substituents with basic centers. Quaternization
Xinlai Cheng, Gerhard Eisenbrand
exaly   +3 more sources

The Role of Indirubins in Inflammation and Associated Tumorigenesis

2016
Indirubin is the major active component of an herbal recipe 'Dangui Luhui Wan' () in traditional Chinese medicine (TCM). It is widely used in China for the treatment of inflammation, cancer, and other chronic diseases and is known for good efficiency and very low side effects.
Xinlai, Cheng, Karl-Heinz, Merz
openaire   +2 more sources

The Effects of Indigotin and Indirubin Pigments on the Dyeability and the Color of Silk Dyed with Indigo and Indirubin Mixed Dye

Journal of the Korean Society of Clothing and Textiles, 2017
This research investigated the effect of pH of dyebath and dyeing temperature on the dyeability of indigotin and indirubin on silk as well as the relationship between the amount of indigotin and indirubin detected from the dyed silk through HPLC-DAD analysis and the color of samples measured using a spectro-colorimeter.
Wansong Yoo, Cheunsoon Ahn
openaire   +1 more source

Improved Synthesis of Indirubin Derivatives by Sequential Build‐Up of the Indoxyl Unit: First Preparation of Fluorescent Indirubins

Helvetica Chimica Acta, 2012
AbstractIndirubin, present in extracts of Isatis tinctoria and some other plant species, has promising cytotoxicity against a variety of cell lines by inhibition of cyclin‐dependent kinases. Chemical synthesis of its derivatives relies on the combination of isatins and 2,3‐dihydro‐1H‐indol‐3‐one (‘indoxyl’) derivatives and usually yields indigo as well
Herbert M. Riepl, Corinna Urmann
openaire   +1 more source

Molecular targets of indirubins

Int. Journal of Clinical Pharmacology and Therapeutics, 2005
S, Jakobs, K H, Merz, S, Vatter, G, Eisenbrand   +3 more
openaire   +2 more sources

Indirubin and Indirubin Derivatives

2008
Gerhard Eisenbrand, Karl-Heinz Merz
openaire   +1 more source

CD44 targeted indirubin nanocrystal-loaded hyaluronic acid hydrogel for the treatment of psoriasis

International Journal of Biological Macromolecules, 2023
Yazhuo Wang
exaly