Results 61 to 70 of about 6,555,116 (242)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Individual tree above-ground biomass estimation by integrating LiDAR and machine learning

Trees, Forests and People
Global warming represents a critical challenge globally, while tree carbon sequestration is essential for achieving carbon neutrality. The existing global allometric models face challenges in accurately modelling local trees’ biomass.
Yan To Choi, Majid Nazeer, Man Sing Wong, Janet Elizabeth Nichol, Shao-Yuan Leu, Jin Wu, Amos P.K. Tai   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Comprehensive Analysis of Cholesteatoma in Chronic Otitis Media: Integrating Traditional Statistical Methods with Machine Learning Approaches

B-ENT
Background: Cholesteatoma detection in chronic otitis media (COM) remains challenging, requiring comprehensive diagnostic approaches. While traditional statistical analysis of individual biomarkers may show limitations, the integration of multiple ...
Merve Çiftçi, Tuba Doğan Karataş, Yusuf Yeşil, Mansur Doğan   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Statistical analysis of alignment characteristics for phrase-based machine translation [PDF]

, 2010
In most statistical machine translation (SMT) systems, bilingual segments are extracted via word alignment. However, there lacks systematic study as to what alignment characteristics can benefit MT under specific experimental settings such as the ...
Petitrenaud, Simon, Patrik Lambert, Andy Way, Lambert, Patrik, Way, Andy, Yanjun Ma, Simon Petitrenaud, Ma, Yanjun   +7 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The need for open source software in machine learning [PDF]

, 2007
Open source tools have recently reached a level of maturity which makes them suitable for building large-scale real-world systems. At the same time, the field of machine learning has developed a large body of powerful learning algorithms for diverse ...
Ratsch, Gunnar, Scholkopf, Bernhard, Vincent, P., LeCun, Y, Ong, C., Braun, M.L., Rasmussen, Carl Edward, Rasmussen, CE, Rätsch, G., Bengio, S., Müller, K.-R., Müller, KR, LeCunn, Yann, Muller, Klaus-Robert, Vincent , P., Pereira, Fernando, Vincent, Pascal, Bottou, Leon, Pereira, F, ,, Braun, ML, Ong, CS, Rasmussen, C.E., Smola, A, Sonnenburg, S., Holmes, G, Bengio, S, Weston, Jason, Williamson, RC, Sonnenburg, S, Williamson, Robert C., Bottou, L., Holmes, G., Ong, Cheng Soon, Pereira, F., Braun, M., Sonnenburg, Soren, Smola, Alexander, Williamson, R.C., Holmes , G., Schölkopf, B, Holmes, Geoffrey, Braun, Mikio L., Bengio, Samy, Schölkopf, B., Rasmussen, C., Williamson, R., Rätch, G, Weston, J, Smola, A., Ong, C.S., Müller, K., Bottou, L, Weston, J., Vincent, P, LeCun, Y.   +55 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source