Results 41 to 50 of about 2,368,157 (325)

Individual Claims History Simulation Machine [PDF]

SSRN Electronic Journal, 2018
The aim of this project is to develop a stochastic simulation machine that generates individual claims histories of non-life insurance claims. This simulation machine is based on neural networks to incorporate individual claims feature information. We provide a fully calibrated stochastic scenario generator that is based on real non-life insurance data.
Andrea Gabrielli, Mario V. Wuthrich
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The optimal crowd learning machine

BioData Mining, 2017
Background Any family of learning machines can be combined into a single learning machine using various methods with myriad degrees of usefulness. Results For making predictions on an outcome, it is provably at least as good as the best machine in the ...
Bilguunzaya Battogtokh, Majid Mojirsheibani, James Malley   +2 more
doaj   +1 more source

N-body Integrators with Individual Time Steps from Hierarchical Splitting

, 2012
We review the implementation of individual particle time-stepping for N-body dynamics. We present a class of integrators derived from second order Hamiltonian splitting.
Aarseth, Chambers, Dehnen, Dubinski, Duncan, Farr, Federico I. Pelupessy, Fujii, Giersz, Hairer, Harfst, Heggie, Hernquist, Hut, Jürgen Jänes, Konstantinidis, Magorrian, Makino, Makino, Mclachlan, McMillan, McMillan, Mikkola, Moore, Nitadori, Portegies Zwart, Portegies Zwart, Preto, Saha, Simon Portegies Zwart, Skeel, Springel, Tuckerman, Wadsley, Wisdom   +34 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Individual Explanations in Machine Learning Models: A Case Study on Poverty Estimation [PDF]

, 2021
Alfredo Carrillo, Luis Fernando Cantú, Luis Tejerina, Alejandro Noriega   +3 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Examining Individual Tax Morale in Europe with Machine-Learning Methods

Central European Public Administration Review
Purpose: This research examines and contributes to the behavioural lit­erature on voluntary tax compliance. It focuses on the use and potential of machine-learning (ML) methods and models to predict individual tax morale across Europe, and it identifies
Lejla Lazović Pita, Almasa Odžak, Lamija Šćeta   +2 more
doaj   +1 more source