Results 51 to 60 of about 533,821 (259)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Individual Identification of Medaka, a Small Freshwater Fish, from the Dorsal Side Using Artificial Intelligence

Hydrobiology
Individual identification is an important ability for humans and perhaps also for non-human animals to lead social lives. It is also desirable for laboratory experiments to keep records of each animal while rearing them in mass.
Mai Osada, Masaki Yasugi, Hirotsugu Yamamoto, Atsushi Ito, Shoji Fukamachi   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Printed sensing human-machine interface with individualized adaptive machine learning

Science Advances
Developing intelligent robots with integrated sensing capabilities is critical for advanced manufacturing, medical robots, and embodied intelligence. Existing robotic sensing technologies are limited to recording of acceleration, driving torque, pressure feedback, and so on.
Guohui Wang, Yao Tang, Xinran Luo, Shengdi Lu, Yiru Zhou, Yi Lu, Guangyang Sun, Pei Liu, Jiayu Ning, Hua Jiang, Ke Hu, Hongzhen Liu, Wenqi Song, You Yu   +13 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Assessing individual genetic susceptibility to metabolic syndrome: interpretable machine learning method

Annals of Medicine
Background Genome-wide association studies have provided profound insights into the genetic aetiology of metabolic syndrome (MetS). However, there is a lack of machine-learning (ML)-based predictive models to assess individual genetic susceptibility to ...
Tao Huang, Yuanyuan Li, Simin Wang, Shijie Qiao, Xiujuan Zheng, Wenhui Xiong, Menghan Yang, Xirui Huang, Bizhen Gao   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Individual tree above-ground biomass estimation by integrating LiDAR and machine learning

Trees, Forests and People
Global warming represents a critical challenge globally, while tree carbon sequestration is essential for achieving carbon neutrality. The existing global allometric models face challenges in accurately modelling local trees’ biomass.
Yan To Choi, Majid Nazeer, Man Sing Wong, Janet Elizabeth Nichol, Shao-Yuan Leu, Jin Wu, Amos P.K. Tai   +6 more
doaj   +1 more source

A Comparison of Machine Learning-Based Individual Mobility Classification Models Developed on Sensor Readings from Loosely Attached Smartphones

Communications, 2020
General mobility estimation is demanded for strategy, policy, systems and services developments and operations in transport, urban development and telecommunications.
Renato Filjar, Ivan Sklebar, Marko Horvat   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source