Results 21 to 30 of about 205,197 (219)

Challenges In Performing An Individual Participant–level Data Meta-analysis

European Urology Focus, 2023
Individual participant-data meta-analysis (IPDMA) uses data at the participant level to synthesize evidence on clinical decision-making. We discuss the differences from aggregate-data meta-analysis and the advantages and challenges of IPDMA. IPDMA provides an opportunity to study effect modifiers at the participant level and can reduce bias in ...
Henk, van der Worp, Gea A, Holtman, Marco H, Blanker   +2 more
openaire   +4 more sources

Testing moderation in network meta‐analysis with individual participant data [PDF]

Statistics in Medicine, 2016
Meta‐analytic methods for combining data from multiple intervention trials are commonly used to estimate the effectiveness of an intervention. They can also be extended to study comparative effectiveness, testing which of several alternative interventions is expected to have the strongest effect.
Dagne, Getachew A., Brown, C. Hendricks, Howe, George, Kellam, Sheppard G., Liu, Lei   +4 more
openaire   +3 more sources

Combining multiple imputation and meta‐analysis with individual participant data [PDF]

Statistics in Medicine, 2013
Multiple imputation is a strategy for the analysis of incomplete data such that the impact of the missingness on the power and bias of estimates is mitigated. When data from multiple studies are collated, we can propose both within‐study and multilevel imputation models to impute missing data on covariates.
Burgess, Stephen, White, Ian R., Resche-Rigon, Matthieu, Wood, Angela M.   +3 more
openaire   +3 more sources

Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis [PDF]

The Lancet Oncology, 2021
Some studies have suggested a link between antihypertensive medication and cancer, but the evidence is so far inconclusive. Thus, we aimed to investigate this association in a large individual patient data meta-analysis of randomised clinical trials.We searched PubMed, MEDLINE, The Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov ...
Emma Copland, Dexter Canoy, Milad Nazarzadeh, Zeinab Bidel, Rema Ramakrishnan, Mark Woodward, John Chalmers, Koon K Teo, Carl J Pepine, Barry R Davis, Sverre Kjeldsen, Johan Sundström, Kazem Rahimi, A Adler, L Agodoa, A Algra, F W Asselbergs, N Beckett, E Berge, H Black, F P J Brouwers, M Brown, C J Bulpitt, B Byington, J Chalmers, W C Cushman, J Cutler, B R Davis, R B Devereaux, J Dwyer, R Estacio, R Fagard, K Fox, T Fukui, A K Gupta, R R Holman, Y Imai, M Ishii, S Julius, Y Kanno, S E Kjeldsen, J Kostis, K Kuramoto, J Lanke, E Lewis, J Lewis, M Lievre, L H Lindholm, S Lueders, S MacMahon, G Mancia, M Matsuzaki, M H Mehlum, S Nissen, H Ogawa, T Ogihara, T Ohkubo, C Palmer, A Patel, C J Pepine, M Pfeffer, N R Poulter, H Rakugi, G Reboldi, C Reid, G Remuzzi, P Ruggenenti, T Saruta, J Schrader, R Schrier, P Sever, P Sleight, J A Staessen, H Suzuki, L Thijs, K Ueshima, S Umemoto, W H van Gilst, P Verdecchia, K Wachtell, P Whelton, L Wing, M Woodward, Y Yui, S Yusuf, A Zanchetti, Z Y Zhang, C Anderson, C Baigent, BM Brenner, R Collins, D de Zeeuw, J Lubsen, E Malacco, B Neal, V Perkovic, B Pitt, A Rodgers, P Rothwell, G Salimi-Khorshidi, J Sundström, F Turnbull, G Viberti, J Wang   +103 more
openaire   +7 more sources

Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

Nature Communications, 2021
The neural mechanisms of placebo analgesia are not fully understood. Here the authors conducted a large scale meta-analysis of individual data from fMRI studies of pain and placebo conditions.
Matthias Zunhammer, Tamás Spisák, Tor D. Wager, Ulrike Bingel, The Placebo Imaging Consortium   +4 more
doaj   +1 more source

Commentary triggered by the Individual Participant Data Meta-Analysis Consortium study of job strain and myocardial infarction risk

Scandinavian Journal of Work, Environment & Health, 2014
Mika Kivimäki initiated the Individual Participant Data (IPD) Meta-Analysis Consortium, which currently has 50 members. The Consortium recently published several research reports on the relationship between job strain (high psychological demands and low ...
Töres Theorell
doaj   +1 more source

Meta-analysis of individual participant data: rationale, conduct, and reporting [PDF]

BMJ, 2010
The use of individual participant data instead of aggregate data in meta-analyses has many potential advantages, both statistically and clinically. Richard D Riley and colleagues describe the rationale for an individual participant data meta-analysis and outline how to conduct this type of study Meta-analysis methods involve combining and analysing ...
Riley, RD, Lambert, PC, Abo-Zaid, G
openaire   +3 more sources

Meta-analysis for individual participant data with a continuous exposure: A case study [PDF]

Journal of Clinical Epidemiology, 2021
Methods for meta-analysis of studies with individual participant data and continuous exposure variables are well described in the statistical literature but are not widely used in clinical and epidemiological research. The purpose of this case study is to make the methods more accessible.A two-stage process is demonstrated.
Darsy Darssan, Gita D. Mishra, Darren C. Greenwood, Sven Sandin, Eric J. Brunner, Sybil L. Crawford, Samar R. El Khoudary, Maria Mori Brooks, Ellen B. Gold, Mette Kildevæld Simonsen, Hsin-Fang Chung, Elisabete Weiderpass, Annette J. Dobson   +12 more
openaire   +6 more sources

Evaluating progestogens for prevention of preterm birth international collaborative (EPPPIC) individual participant data (IPD) meta-analysis: protocol

Systematic Reviews, 2017
Background Preterm birth is the most common cause of death and harm to newborn babies. Babies that are born early may have difficulties at birth and experience health problems during early childhood.
Lesley A. Stewart, Mark Simmonds, Lelia Duley, Kristina Charlotte Dietz, Melissa Harden, Alex Hodkinson, Alexis Llewellyn, Sahar Sharif, Ruth Walker, Kath Wright, the EPPPIC group   +10 more
doaj   +1 more source

Immunogenicity and seroefficacy of 10-valent and 13-valent pneumococcal conjugate vaccines: a systematic review and network meta-analysis of individual participant dataResearch in context

EClinicalMedicine, 2023
Summary: Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) is recommended by the World Health Organization. Evidence is mixed regarding the differences in immunogenicity and efficacy of the different pneumococcal vaccines ...
Shuo Feng, Julie McLellan, Nicola Pidduck, Nia Roberts, Julian P.T. Higgins, Yoon Choi, Alane Izu, Mark Jit, Shabir A. Madhi, Kim Mulholland, Andrew J. Pollard, Beth Temple, Merryn Voysey   +12 more
doaj   +1 more source