Results 61 to 70 of about 43,105,901 (290)

Analyzing data of a multilab replication project with individual participant data meta-analysis: A tutorial [PDF]

Zeitschrift für Psychologie, 2020
Multilab replication projects such as Registered Replication Reports (RRR) and Many Labs projects are used to replicate an effect in different labs. Data of these projects are usually analyzed using conventional meta-analysis methods. This is certainly not the best approach, because it does not make optimal use of the available data as summary rather ...
openaire   +4 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Identifying relapse predictors in individual participant data with decision trees

BMC Psychiatry, 2023
Background Depression is a highly common and recurrent condition. Predicting who is at most risk of relapse or recurrence can inform clinical practice. Applying machine-learning methods to Individual Participant Data (IPD) can be promising to improve the
Lucas Böttcher, Josefien J. F. Breedvelt, Fiona C. Warren, Zindel Segal, Willem Kuyken, Claudi L. H. Bockting   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Mortality After Release from Incarceration Consortium (MARIC): Protocol for a multi-national, individual participant data meta-analysis

International Journal of Population Data Science, 2020
Introduction More than 30 million adults are released from incarceration globally each year. Many experience complex physical and mental health problems, and are at markedly increased risk of preventable mortality.
Rohan Borschmann, Holly Tibble, Matthew J Spittal, David Preen, Jane Pirkis, Sarah Larney, David L Rosen, Jesse T Young, Alexander D Love, Frederick L Altice, Ingrid A Binswanger, Anne Bukten, Tony Butler, Zheng Chang, Chuan-Yu Chen, Thomas Clausen, Peer Brehm Christensen, Gabriel J Culbert, Louisa Degenhardt, Anja J.E. Dirkzwager, Kate Dolan, Seena Fazel, Colin Fischbacher, Margaret Giles, Lesley Graham, David Harding, Yen-Fang Huang, Florence Huber, Azar Karaminia, Fiona G Kouyoumdjian, Sungwoo Lim, Lars Møller, Akm Moniruzzaman, Jeffrey Morenoff, Eamonn O'Moore, Lia N Pizzicato, Daniel Pratt, Scott F Proescholdbell, Shabbar I Ranapurwala, Meghan E Shanahan, Jenny Shaw, Julian M Somers, Anne C Spaulding, Marc F Stern, Kendra M Viner, Nadia Wang, Melissa Willoughby, Stuart A Kinner   +47 more
doaj   +1 more source

Appendix for: Association of gestational free and total triiodothyronine with gestational hypertension, preeclampsia, preterm birth and birth weight: an individual-participant data meta-analysis

, 2023
Appendix for: Association of gestational free and total triiodothyronine with gestational hypertension, preeclampsia, preterm birth and birth weight: an individual-participant data meta ...
Derakhshan (9872903)
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis

The Lancet Microbe
Summary: Background: Translation of blood RNA signatures might be accelerated by identifying biomarkers composed of the minimum number of gene transcripts.
James Greenan-Barrett, MRCP, Simon C Mendelsohn, PhD, ProfPhD Thomas J Scriba, PhD, ProfPhD Mahdad Noursadeghi, PhD, Rishi K Gupta, PhD   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source