Results 81 to 90 of about 43,105,901 (290)

Pathobionts in the Vaginal Microbiota: Individual Participant Data Meta-Analysis of Three Sequencing Studies

Frontiers in Cellular and Infection Microbiology, 2020
Sequencing studies have shown that optimal vaginal microbiota (VMB) are lactobacilli-dominated and that anaerobes associated with bacterial vaginosis (BV-anaerobes) are commonly present. However, they overlooked a less prevalent but more pathogenic group
Janneke H. H. M. van de Wijgert, Janneke H. H. M. van de Wijgert, Marijn C. Verwijs, A. Christina Gill, Hanneke Borgdorff, Charlotte van der Veer, Philippe Mayaud   +6 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Estimating reference intervals from an IPD meta-analysis using quantile regression

BMC Medical Research Methodology
Background Reference intervals, which define an interval in which a specific proportion of measurements from a healthy population are expected to fall, are commonly used in medical practice.
Ziren Jiang, Haitao Chu, Zhen Wang, M. Hassan Murad, Lianne K. Siegel   +4 more
doaj   +1 more source

Individual participant data meta-analysis of continuous outcomes: A comparison of approaches for specifying and estimating one-stage models [PDF]

, 2018
One-stage individual participant data meta-analysis models should account for within-trial clustering, but it is currently debated how to do this.

core   +1 more source

Get real in individual participant data (IPD) meta‐analysis: a review of the methodology

Research Synthesis Methods, 2015
Individual participant data (IPD) meta‐analysis is an increasingly used approach for synthesizing and investigating treatment effect estimates. Over the past few years, numerous methods for conducting an IPD meta‐analysis (IPD‐MA) have been proposed, often making different assumptions and modeling choices while addressing a similar research question ...
Debray, Thomas P. A., Moons, Karel G. M., van Valkenhoef, Gert, Efthimiou, Orestis, Hummel, Noemi, Groenwold, Rolf H. H., Reitsma, Johannes B., Belger, Mark, Bozzi, Silvie, Carreras, Maximo, Ho, F., Egger, Matthias, Fletcher, Christine, Gsteiger, Sandro, Kilcher, Gablu, Kitio-Dschassi, Brice, Makady, Amr, Panayidou, Klea, Salanti, Georgia, Shang, Aijing, Trelle, Sven, Monz, Brigitta   +21 more
openaire   +3 more sources

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Statistical approaches to identify subgroups in meta-analysis of individual participant data: a simulation study

BMC Medical Research Methodology, 2019
Background Individual participant data meta-analysis (IPD-MA) is considered the gold standard for investigating subgroup effects. Frequently used regression-based approaches to detect subgroups in IPD-MA are: meta-regression, per-subgroup meta-analysis ...
Michail Belias, Maroeska M. Rovers, Johannes B. Reitsma, Thomas P. A. Debray, Joanna IntHout   +4 more
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis.

PLoS Medicine, 2015
BackgroundObservational studies of a putative association between hormonal contraception (HC) and HIV acquisition have produced conflicting results. We conducted an individual participant data (IPD) meta-analysis of studies from sub-Saharan Africa to ...
Charles S Morrison, Pai-Lien Chen, Cynthia Kwok, Jared M Baeten, Joelle Brown, Angela M Crook, Lut Van Damme, Sinead Delany-Moretlwe, Suzanna C Francis, Barbara A Friedland, Richard J Hayes, Renee Heffron, Saidi Kapiga, Quarraisha Abdool Karim, Stephanie Karpoff, Rupert Kaul, R Scott McClelland, Sheena McCormack, Nuala McGrath, Landon Myer, Helen Rees, Ariane van der Straten, Deborah Watson-Jones, Janneke H H M van de Wijgert, Randy Stalter, Nicola Low   +25 more
doaj   +1 more source

Exercise therapy for chronic low back pain: protocol for an individual participant data meta-analysis

, 2012
BACKGROUND: Low back pain (LBP) is one of the leading causes of disability and has a major socioeconomic impact. Despite a large amount of research in the field, there remains uncertainty about the best treatment approach for chronic LBP, and ...
Riley, RD, Chronic, Low Back Pain IPD Meta-Analysis Group, Hayden, JA, Cartwright, JL, Vantulder, MW   +4 more
core   +1 more source