Results 121 to 130 of about 13,873 (237)

Validation of a high performance functional assay for individual radiosensitivity in pediatric oncology: a prospective cohort study (ARPEGE). [PDF]

BMC Cancer, 2018
Bernier-Chastagner V, Hettal L, Gillon V, Fernandes L, Huin-Schohn C, Vazel M, Tosti P, Salleron J, François A, Cérimèle E, Perreira S, Peiffert D, Chastagner P, Vogin G.   +13 more
europepmc   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source

Near‐Infrared Triggered Rechargeable Singlet Oxygen Battery for Sustained Phototherapy: Fast Charging and Long‐Lasting Discharging

Advanced Science, EarlyView.
A near‐infrared‐triggered rechargeable singlet oxygen battery based on PBDP nanoparticles is developed. Upon 808 nm irradiation for 5 min, the system enables efficient singlet oxygen generation, reversible storage via cycloaddition, and sustained release for up to 1 h after light cessation.
Yuxin Ren, Ling Li, Xinyi Zhang, Meiqi Li, Junqing Wang, Mengpan Zhang, Jian Wang, Yanli Tang   +7 more
wiley   +1 more source

MagGami: An Electromagnetic Origami Actuator With High Stiffness‐Switching Density for Lightweight Joint‐Space Wearable Haptics

Advanced Science, EarlyView.
Concept of the MagGami‐based joint‐space haptic glove. a) Comparison between Cartesian‐space fingertip force feedback and distributed joint‐space torque feedback, highlighting the limitations of representative motor‐driven, pneumatic, and smart material‐based haptic actuators.
Tianhao Jin, Zirui Niu, Qingyun Tang, Zemin Wang, Yu Qiao, Guocai Yao, Yong Zhou, Boxue Shan, Yan Zhang, Dangxiao Wang   +9 more
wiley   +1 more source

Metasurface‐Based Multidimensional Light‐Field Manipulation: From Technologies to Applications

Advanced Science, EarlyView.
Multidimensional metasurfaces enable versatile manipulation of multiple optical degrees of freedom, including phase, amplitude, polarization, wavelength, and orbital angular momentum. This review summarizes their fundamental mechanisms, emerging strategies for multidimensional light‐field control, and key applications in optical computing, imaging ...
Heliang Yin, Shuo Sun, Jiahao Zhang, Jianuo Hu, Yubin Qiao, Liang Chen, Jin Li   +6 more
wiley   +1 more source

Spatiotemporally Precise Rheumatoid Arthritis Therapy via a Triple‐Locked Cascaded Nanoplatform With Dual‐Channel Self‐Reporting

Advanced Science, EarlyView.
An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Jihong Liu, Wendi Zhu, Shiyun Xu, Shichang Liu, Wenjun Tang, Xiaoyu Ma, Ting Yang, Haojian Yang, Hongtong Wang, Lu Cao, Lijie Tan, Qi Wang   +11 more
wiley   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source