Results 1 to 10 of about 9,283 (84)

Chromosomal Radiosensitivity in Sjögren’s Syndrome with and Without Concomitant Malignancy [PDF]

Cells
Connective tissue diseases have long been hypothesized to confer increased radiosensitivity and radiotherapy-related toxicity, although findings vary between disease entities.
Elena Strljic, Lukas Kuhlmann, Jochen Wacker, Hans Geinitz, Stefanie Corradini, Georg Schett, Luitpold V. Distel, Hannah Schenker   +7 more
doaj   +2 more sources

Breast cancer risk genes affecting individual radiosensitivity [PDF]

Scientific Reports
Increased radiosensitivity can cause adverse radiotherapy effects. Heterozygote variants in breast cancer risk genes increase cancer risk and may affect radiosensitivity.
Ramona K. G. Vogel, Niklas Amann, Tara Zuhair Kassem, Paul Gaß, Theresa Mayo, Felix Woltereck, Carolin C. Hack, Rainer Fietkau, Stefanie Corradini, Luitpold Distel, Lukas C. F. Kuhlmann   +10 more
doaj   +2 more sources

Chromosomal radiosensitivity in oncological and non-oncological patients with rheumatoid arthritis and connective tissue diseases

Radiation Oncology, 2023
Background The risk of developing late radiotoxicity after radiotherapy in patients with high chromosomal radiosensitivity after radiotherapy could potentially be higher compared to the risk in patients with average radiosensitivity. In case of extremely
Dinah Rzepka, Hannah Schenker, Hans Geinitz, Elisabeth Silberberger, Dorothee Kaudewitz, Barbara Schuster, Lukas Kuhlmann, Miriam Schonath, Horacio Ayala Gaona, Bernhard Aschacher, Rainer Fietkau, Georg Schett, Luitpold Distel   +12 more
doaj   +1 more source

Ex vivo radiosensitivity is increased in non-cancer patients taking valproate

BMC Neurology, 2020
Background Valproate (VPA) is a commonly prescribed antiepileptic drug for patients experiencing epileptic seizures due to brain tumors. VPA increases radiation sensitivity in various tumor cells in vitro due to complex mechanisms. This could make tumors
Jenny Stritzelberger, Jennifer Lainer, Stefanie Gollwitzer, Wolfgang Graf, Tina Jost, Johannes D. Lang, Tamara M. Mueller, Stefan Schwab, Rainer Fietkau, Hajo M. Hamer, Luitpold Distel   +10 more
doaj   +1 more source

Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes BReast CAncer 1 and BReast CAncer 2

Current Issues in Molecular Biology, 2023
Background: Individual radiosensitivity is an important factor in the occurrence of undesirable consequences of radiotherapy. The potential for increased radiosensitivity has been linked to highly penetrant heterozygous mutations in DNA repair genes such
Tara Zuhair Kassem, Marius Wunderle, Lukas Kuhlmann, Matthias Ruebner, Hanna Huebner, Juliane Hoyer, André Reis, Peter A. Fasching, Matthias W. Beckmann, Carolin C. Hack, Rainer Fietkau, Luitpold Distel   +11 more
doaj   +1 more source

Increased Radiation Sensitivity in Patients with Phelan-McDermid Syndrome

Cells, 2023
Phelan-McDermid syndrome is an inherited global developmental disorder commonly associated with autism spectrum disorder. Due to a significantly increased radiosensitivity, measured before the start of radiotherapy of a rhabdoid tumor in a child with ...
Sarah Jesse, Lukas Kuhlmann, Laura S. Hildebrand, Henriette Magelssen, Martina Schmaus, Beate Timmermann, Stephanie Andres, Rainer Fietkau, Luitpold V. Distel   +8 more
doaj   +1 more source

Clastogenic Effects of Thyme Essential Oil on Vicia faba

Chemistry Proceedings, 2022
Indiscriminate use of pesticides in agriculture has many negative implications on both abiotic and biotic components of the environment [1]. One of the alternative methods to maintaining productivity and quality of life is using compounds produced by the
Victoria Bînzari, Denisa-Ioana Gheorghe, Carmen Lupu, Diana Constantinescu-Aruxandei, Florin Oancea   +4 more
doaj   +1 more source

Individual sensitivity to cytogenetic effects of benzo[alpha]pyrene in cultured human lymphocytes: influence of glutathione S-transferase M1 genotype

Genetics and Molecular Biology, 2006
Sister chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes has been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[alpha]pyrene (BaP).
Gülgün S. Güven, Mehmet Güven, Ilhan Onaran, Turgut Ulutin, Seniha Hacihanefioglu   +4 more
doaj   +1 more source

Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients

BMC Geriatrics, 2018
Background The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual ...
Barbara Schuster, Anna Ellmann, Theresa Mayo, Judith Auer, Matthias Haas, Markus Hecht, Rainer Fietkau, Luitpold V. Distel   +7 more
doaj   +1 more source

Application of mutagen sensitivity assay in a glioma case-control study

Toxicology Reports, 2018
Few risk factors for glioma have been identified other than ionizing radiation. The alkylating agent acrylamide is a compound found in both occupational and the general environment and identified as one of the forty known or suspected neurocarcinogens in
Serap Erdal, Bridget J. McCarthy, Natalia Gurule, Marianne Berwick, Emily Gonzales, Johanna Byrd, Kristina Flores, JoAnna Shimek, Dora Il’yasova, Francis Ali-Osman, Darell D. Bigner, Faith G. Davis, Alexis N. Leyba, Kirsten A.M. White   +13 more
doaj   +1 more source