Results 21 to 30 of about 5,403,021 (155)
Advanced Science, EarlyView.This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang +8 more
wiley +1 more source
Effect of vorinostat on DEB-induced chromosome fragility of FA lymphocytes.
, 2015 (A) Lymphocytes metaphase without treatment. (B) Lymphocyte metaphase treated with DEB. (C) Lymphocyte metaphase treated with DEB after Vorinostat treatment. The red arrows indicate aberrant chromosomes characteristic of FA cells.
Jordi Surralles (5665636) +13 more
core +1 more source
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source
, 2015 (A) Representative metaphase spreads. Arrows indicate chromosomal or chromatid breaks. (B) Number of chromosomal breaks and chromatid breaks, shown as a table. (C) Sequence electropherogram of Kmt2a-Ptp4a2 fusion mRNA.
Masatoshi Takagi (254459) +5 more
core +1 more source
Advanced Science, EarlyView.Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu +14 more
wiley +1 more source
Expression of G199S leads to induction of chromosomal aberrations.
, 2014 Representative image of metaphase spreads of MCF10A pools expressing (A) WT or (B) G199S. Chromosomal breaks are noted with arrows and fusions are noted with *. C. Graph illustrating the average number of aberrations per metaphase. A total of at least 50
Sylvie Doublié (280774) +6 more
core +1 more source
Optimal Forecasts in the Presence of Structural Breaks [PDF]
, 2012 This paper considers the problem of forecasting under continuous and discrete structural breaks and proposes weighting observations to obtain optimal forecasts in the MSFE sense.
core +3 more sources
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli
Advanced Science, EarlyView.Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma +18 more
wiley +1 more source