Results 11 to 20 of about 5,403,021 (155)

A role for topoisomerase II alpha in chromosome damage in human cell lines [PDF]

, 2010
Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations.
Terry, Samantha Y.A.
core   +2 more sources

Effect of Methotrexate and Omega-3 Combination on Cytogenetic Changes of Bone Marrow and Some Enzymatic Antioxidants: An Experimental Study

Yemeni Journal for Medical Sciences, 2017
Introduction Methods Resuts Discussion Conclusions Acknowledgments Authors' contributions Competing interests Ethical approval References Effect of Methotrexate and Omega-3 Combination on Cytogenetic Changes of Bone Marrow and Some ...
Inaam N. Ali, Muthana M. Awad, Alaa S. Mahmood   +2 more
doaj   +3 more sources

DNA damage in the kidney tissue cells of the fish Rhamdia quelen after trophic contamination with aluminum sulfate

Genetics and Molecular Biology, 2015
Even though aluminum is the third most common element present in the earth's crust, information regarding its toxicity remains scarce. It is known that in certain cases, aluminum is neurotoxic, but its effect in other tissues is unknown.
Tatiane Klingelfus, Paula Moiana da Costa, Marcos Scherer, Marta Margarete Cestari   +3 more
doaj   +1 more source

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases [PDF]

, 2010
During mitosis in most eukaryotic cells, chromosomes align and form a metaphase plate halfway between the spindle poles, about which they exhibit oscillatory movement. These movements are accompanied by changes in the distance between sister kinetochores,
Porter, Iain M.; id_orcid, McClelland, Sarah E., King, E. M., Toso, Alberto, Swedlow, Jason, Swedlow, Jason R.; id_orcid, McClelland, S. E., Meraldi, P., Gaudenz Danuser, McAinsh, Andrew D., Posch, Markus, Emma M. King, Dorn, J. F., King, Emma M., Andrew D. McAinsh, Winter, J. R., Iain M. Porter, Khuloud Jaqaman, Ana C. Amaro, Mchedlishvili, N., Dorn, Jonas F., Toso, A., Porter, I. M., Posch, M., Winter, Jennifer R., Jonas F. Dorn, Jason R. Swedlow, Jaqaman, Khuloud, Jennifer R. Winter, Sarah E. McClelland, Jaqaman, K., Amaro, Ana C., Danuser, Gaudenz, Porter, Iain M., Danuser, G., Markus Posch, Elliott, Hunter L., Swedlow, Jason R., Amaro, A. C., Nunu Mchedlishvili, Alberto Toso, Hunter L. Elliott, Patrick Meraldi, Mchedlishvili, Nunu, Meraldi, Patrick   +44 more
core   +1 more source

Metaphase-arrested spindles remain stable without auxin treatment.

, 2022
Shows a metaphase-arrested oocyte expressing mCherry::tubulin (left) and degron::GFP::ZYG-9 (right), dissected into a control Meiosis medium solution. Corresponds to Fig 2A. No major changes in spindle length or shape occur. Note that the spindle rotates
Justin D. Finkle (10870793), Sarah M. Wignall (3013278), Timothy J. Mullen (4436281), Emily R. Czajkowski (14197638), Ian D. Wolff (14197641), Nikita S. Divekar (5714540), Gabriel Cavin-Meza (14197635)   +6 more
core   +1 more source

Is in vivo and ex vivo irradiation equally reliable for individual Radiosensitivity testing by three colour fluorescence in situ hybridization?

Radiation Oncology, 2019
Background Individual radiosensitivity is influencing the outcome of radiation therapy. A general ex vivo testing is very work-intensive. It is of interest to see if a significant prediction concerning the sensitivity can be made by in vivo irradiation ...
Theresa Mayo, Marlen Haderlein, Barbara Schuster, Anna Wiesmüller, Christian Hummel, Maximilian Bachl, Manfred Schmidt, Rainer Fietkau, Luitpold Distel   +8 more
doaj   +1 more source

Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules [PDF]

, 1993
The frequency of DNA double-strand breaks (dsb) was determined in yeast cells exposed to γ-rays under anoxic conditions. Genomic DNA of treated cells was separated by pulsed field gel electrophoresis, and two different approaches for the evaluation of ...
Beisker, W., Eckardt-Schupp, F., Kellerer, Albrecht M., Eckard-Schupp, F., Friedl, A.A., Kellerer, A.M., Hahn, K.R., Friedl, Anna A., Hahn, K., K. Hahn, A.M. Kellerer, F. Eckardt-Schupp, A.A. Friedl, W. Beisker   +13 more
core   +1 more source

Analysis of the Relationships between DNA Double-Strand Breaks, Synaptonemal Complex and Crossovers Using the Atfas1-4 Mutant.

PLoS Genetics, 2015
Chromatin Assembly Factor 1 (CAF-1) is a histone chaperone that assembles acetylated histones H3/H4 onto newly synthesized DNA, allowing the de novo assembly of nucleosomes during replication.
Javier Varas, Eugenio Sánchez-Morán, Gregory P Copenhaver, Juan L Santos, Mónica Pradillo   +4 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Metaphase spreads of SCNT-derived, 2–4 cell stage embryos.

, 2013
Normal metaphase spreads with 54 chromosomes from embryos obtained by injection of nuclei from (a) fresh, (c) frozen and (e) freeze-dried lymphocytes.
Grazyna Ptak (289969), Michal Bochenek (289960), Silvestre Sampino (289955), Marta Czernik (289953), Federica Zacchini (289957), Zdzislaw Smorag (289963), Jacek A. Modlinski (289966), Domenico Iuso (289952), Pasqualino Loi (289972), Fiorella Di Egidio (289954)   +9 more
core   +1 more source