Results 1 to 10 of about 30,782 (116)

Chromosomal Radiosensitivity in Sjögren’s Syndrome with and Without Concomitant Malignancy [PDF]

Cells
Connective tissue diseases have long been hypothesized to confer increased radiosensitivity and radiotherapy-related toxicity, although findings vary between disease entities.
Elena Strljic, Lukas Kuhlmann, Jochen Wacker, Hans Geinitz, Stefanie Corradini, Georg Schett, Luitpold V. Distel, Hannah Schenker   +7 more
doaj   +2 more sources

Breast cancer risk genes affecting individual radiosensitivity [PDF]

Scientific Reports
Increased radiosensitivity can cause adverse radiotherapy effects. Heterozygote variants in breast cancer risk genes increase cancer risk and may affect radiosensitivity.
Ramona K. G. Vogel, Niklas Amann, Tara Zuhair Kassem, Paul Gaß, Theresa Mayo, Felix Woltereck, Carolin C. Hack, Rainer Fietkau, Stefanie Corradini, Luitpold Distel, Lukas C. F. Kuhlmann   +10 more
doaj   +2 more sources

The Cell Cycle G2/M Block Is an Indicator of Cellular Radiosensitivity

Dose-Response, 2019
Background: Determination of the radiosensitivity of a specific tumor is essential to its precision tumor radiotherapy, but the measurement of cellular radiosensitivity with a routine colony forming assay is both labor- and time-consuming. An alternative
Weidong Mao, Chang Liu
exaly   +2 more sources

Mapping radiosensitivity in glioblastoma using MR elastography and biomechanical modeling [PDF]

Scientific Reports
Glioblastoma multiforme (GBM) remains a devastating disease with a poor prognosis. GBM progression generates mechanical forces that compromise blood vessels’ functionality, impair perfusion, and create hypoxic regions, which in turn reduce ...
Constantinos Harkos, Kyprianos Dimou, Marina Koutsi, Yiannis Roussakis, Siri Fløgstad Svensson, Kyrre E. Emblem, Constantinos Zamboglou, Triantafyllos Stylianopoulos   +7 more
doaj   +2 more sources

Chromosomal radiosensitivity in oncological and non-oncological patients with rheumatoid arthritis and connective tissue diseases

Radiation Oncology, 2023
Background The risk of developing late radiotoxicity after radiotherapy in patients with high chromosomal radiosensitivity after radiotherapy could potentially be higher compared to the risk in patients with average radiosensitivity. In case of extremely
Dinah Rzepka, Hannah Schenker, Hans Geinitz, Elisabeth Silberberger, Dorothee Kaudewitz, Barbara Schuster, Lukas Kuhlmann, Miriam Schonath, Horacio Ayala Gaona, Bernhard Aschacher, Rainer Fietkau, Georg Schett, Luitpold Distel   +12 more
doaj   +1 more source

Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis

Open Medicine, 2023
Radiotherapy resistance is a challenge for colorectal cancer (CRC) treatment. Circular RNAs (circRNAs) play vital roles in the occurrence and development of CRC.
Wang Ximin, Zheng Dongxu, Wang Changting, Chen Wanhua   +3 more
doaj   +1 more source

Circ_0007580 knockdown strengthens the radiosensitivity of non‐small cell lung cancer via the miR‐598‐dependent regulation of THBS2

Thoracic Cancer, 2022
Background Radioresistance is a common cause of treatment failure in many cancers, including non‐small cell lung cancer (NSCLC). Circular RNA (circRNA) has been shown to be involved in the radiosensitivity of many cancers. However, the role and mechanism
Zheng Yang, Hongfang Wu, Kai Zhang, Shilei Rao, Shuran Qi, Manxiang Liu, Ying Chen, Yang Wang   +7 more
doaj   +1 more source

Predicting Normal Tissue Radiotoxicity in Radiotherapy Patients Based on the Individual Radiosensitivity Using Three-Color Fluorescence In Situ Hybridization: A Literature Review

Indonesian Journal of Cancer, 2022
Background: The variability of clinical response in radiotherapy (RT) patients revealed that individual radiosensitivity exists in humans. Although several techniques for radiosensitivity assessment are available, fluorescence in situ hybridization (FISH)
Dwi Ramadhani , Isnaini Farida, Arum Wulansari , Wiwin Mailana, Hartini Ahadiyatur Ru’yi, Syarifatul Ulya, Sofiati Purnami, Nastiti Rahajeng, Devita Tetriana, Iin Kurnia, Mukh Syaifudin   +10 more
doaj   +1 more source

Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes BReast CAncer 1 and BReast CAncer 2

Current Issues in Molecular Biology, 2023
Background: Individual radiosensitivity is an important factor in the occurrence of undesirable consequences of radiotherapy. The potential for increased radiosensitivity has been linked to highly penetrant heterozygous mutations in DNA repair genes such
Tara Zuhair Kassem, Marius Wunderle, Lukas Kuhlmann, Matthias Ruebner, Hanna Huebner, Juliane Hoyer, André Reis, Peter A. Fasching, Matthias W. Beckmann, Carolin C. Hack, Rainer Fietkau, Luitpold Distel   +11 more
doaj   +1 more source

A Radiosensitivity Prediction Model Developed Based on Weighted Correlation Network Analysis of Hypoxia Genes for Lower-Grade Glioma

Frontiers in Oncology, 2022
Background and PurposeHypoxia is one of the basic characteristics of the physical microenvironment of solid tumors. The relationship between radiotherapy and hypoxia is complex.
Zixuan Du, Zixuan Du, Hanshan Liu, Lu Bai, Lu Bai, Derui Yan, Huijun Li, Sun Peng, JianPing Cao, Song-Bai Liu, Zaixiang Tang   +10 more
doaj   +1 more source