Results 21 to 30 of about 30,881 (212)

Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells

BMC Genomics, 2012
Background In the postgenome era, a prediction of response to treatment could lead to better dose selection for patients in radiotherapy. To identify a radiosensitive gene signature and elucidate related signaling pathways, four different microarray ...
Kim Han, Kim Sang, Kim Sun, Park Chan, Jeung Hei-Cheul, Kim Yong, Ahn Joong, Chung Hyun, Rha Sun   +8 more
doaj   +1 more source

Intrinsic Radiosensitivity and Cellular Characterization of 27 Canine Cancer Cell Lines. [PDF]

PLoS ONE, 2016
Canine cancer cell lines have progressively been developed, but are still underused resources for radiation biology research. Measurement of the cellular intrinsic radiosensitivity is important because understanding the difference may provide a framework
Junko Maeda, Coral E Froning, Colleen A Brents, Barbara J Rose, Douglas H Thamm, Takamitsu A Kato   +5 more
doaj   +1 more source

Short-Term Hyperosmolality Pretreatment on Cells Can Reduce the Radiosensitivity via RVI and Akt1 Activation

Cellular Physiology and Biochemistry, 2013
Background/Aims: The ionizing radiation (IR) has been applied in clinical treatment for many years and the radiosensitivity is crucial to the treatment. Radiosensitivity of cells is subjected to many environmental factors, such as hypoxia and temperature.
Hu Liu, Yijuan Huang, Wei Zhang, Zhilin Sha, Bailong Li, Yanyong Yang, Wen Liu, Chao Zhang, Fu Gao, Jianming Cai   +9 more
doaj   +1 more source

CircATIC inhibits esophageal carcinoma progression and promotes radiosensitivity by elevating RHCG through sponging miR‐10‐3p

Thoracic Cancer, 2022
Background Circular RNAs (circRNAs) are implicated in the progression and radiosensitivity of human cancers, including esophageal carcinoma (ESCA). In this study, we aimed to explore the functions of circRNA 5‐aminoimidazole‐4‐carboxamide ribonucleotide ...
Kai Zhang, Ruitai Fan, Deyao Zhao, Peipei Liu, Zheng Yang, Junqi Liu, Song Zhang, Shilei Rao, Yang Wang, Lixin Wan   +9 more
doaj   +1 more source

PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer

Frontiers in Oncology, 2022
ObjectiveInsensitivity to radiotherapy accounts for the majority of therapeutic failures in cervical cancer (CC) patients who undergo radical radiotherapy.
Zhuna Wu, Zhuna Wu, Zhuna Wu, Chunxian Huang, Chunxian Huang, Ruixin Li, Ruixin Li, Hui Li, Hui Li, Huaiwu Lu, Huaiwu Lu, Zhongqiu Lin, Zhongqiu Lin   +12 more
doaj   +1 more source

Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Radiation Oncology, 2019
Background Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity.
J. C. L. Alfonso, L. Berk
doaj   +1 more source

Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM. [PDF]

PLoS ONE, 2012
There are contradictory observations about the different radiosensitivities of cancer stem cells and cancer non-stem cells. To resolve these contradictory observations, we studied radiosensitivities by employing breast cancer stem cell (CSC)-like MDA ...
Seog-Young Kim, Juong G Rhee, Xinxin Song, Edward V Prochownik, Douglas R Spitz, Yong J Lee   +5 more
doaj   +1 more source

Research Progress on Energy Metabolism and Radiosensitivity of Glioma

Zhongliu Fangzhi Yanjiu, 2021
Radiotherapy is an important auxiliary treatment for glioma. Although comprehensive treatment of glioma has made some progress in recent years, the prognosis is still poor.
MOU Fuling, ZHONG Jiawei, SUN Pengfei
doaj   +1 more source

Discovery of a DNA repair-associated radiosensitivity index for predicting radiotherapy efficacy in breast cancer

Frontiers in Oncology
PurposeRadiotherapy is a cornerstone of breast cancer (BRCA) treatment. Accurately predicting tumor radiosensitivity is critical for optimizing therapeutic outcomes and personalizing treatment strategies.
Jianguang Lin, Hainan Yang, Rongfu Huang, Tianwen Xu   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source