Results 11 to 20 of about 30,881 (212)

Integrating Radiosensitivity Gene Signature Improves Glioma Outcome and Radiotherapy Response Prediction

Medicina, 2022
Response to radiotherapy (RT) in gliomas varies widely between patients. It is necessary to identify glioma-associated radiosensitivity gene signatures for clinically stratifying patients who will benefit from adjuvant radiotherapy after glioma surgery ...
Shan Wu, Jing Xu, Guang Li, Xi Jin
doaj   +1 more source

A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials

Scientific Reports, 2017
Personalized cancer therapy seeks to tailor treatment to an individual patient’s biology. Therefore, a means to characterize radiosensitivity is necessary. In this study, we investigated radiosensitivity in the normal esophagus using an imaging biomarker
Joshua S. Niedzielski, Jinzhong Yang, Francesco Stingo, Zhongxing Liao, Daniel Gomez, Radhe Mohan, Mary Martel, Tina Briere, Laurence Court   +8 more
doaj   +1 more source

Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101

Frontiers in Genetics, 2018
Background: The aim of the present study was to identify the potential long non-coding (lnc.)-RNA and its associated molecular mechanisms involved in the regulation of the radiosensitivity of esophageal squamous cell cancer (ESCC) in order to assess ...
Mingqiu Chen, Mingqiu Chen, Mingqiu Chen, Pingping Liu, Yuangui Chen, Zhiwei Chen, Minmin Shen, Xiaohong Liu, Xiqing Li, Anchuan Li, Yu Lin, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Ye Tian, Ye Tian, Jiancheng Li, Junqiang Chen   +18 more
doaj   +1 more source

Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients

BMC Geriatrics, 2018
Background The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual ...
Barbara Schuster, Anna Ellmann, Theresa Mayo, Judith Auer, Matthias Haas, Markus Hecht, Rainer Fietkau, Luitpold V. Distel   +7 more
doaj   +1 more source

Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3

Cancer Biology & Therapy, 2023
As the most common histological subtype of primary lung cancer, lung adenocarcinoma (LUAD) causes enormous cancer deaths worldwide. Radiotherapy has been frequently used in LUAD cases, and radiosensitivity is vital for LUAD therapy.
Chongxin Li, Yanyan Fu, Yongmei He, Nan Huang, Jun Yue, Yi Miao, Jialing Lv, Youchuan Xiao, Ruoyu Deng, Chao Zhang, Meifang Huang   +10 more
doaj   +1 more source

ALKBH5/YTHDF2‐mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation

Clinical and Translational Medicine, 2023
Background Circular RNA (circRNA) and N6‐methyladenosine (m6A) play a critical role in tumour occurrence and development, including colorectal cancer (CRC). However, little is known about the interaction between circRNA and m6A in the radiosensitivity of
Yingjie Shao, Zhenhua Liu, Xing Song, Rui Sun, You Zhou, Dachuan Zhang, Huihui Sun, Junchao Huang, Chenxi Wu, Wendong Gu, Xiao Zheng, Jingting Jiang   +11 more
doaj   +1 more source

A novel role for apatinib in enhancing radiosensitivity in non-small cell lung cancer cells by suppressing the AKT and ERK pathways [PDF]

PeerJ, 2021
Background Radioresistance is still the major cause of radiotherapy failure and poor prognosis in patients with non-small cell lung cancer (NSCLC). Apatinib (AP) is a highly selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2 ...
Lin Li, Yuexian Li, Huawei Zou
doaj   +2 more sources

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response. [PDF]

Adv Sci (Weinh)
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Yang T, Shen T, Qiu Y, Zhang W, Zheng Z, Sun J, Yao Y, Yao M, Li J.   +8 more
europepmc   +2 more sources

Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells

Scientific Reports, 2017
Ionizing radiation (IR) induces DNA double-strand breaks (DSBs), which are an initial step towards chromosomal aberrations and cell death. It has been suggested that there are individual differences in radiosensitivity within human populations, and that ...
Ekaterina Royba, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Kosuke Hosoba, Hiroshi Tauchi, Yoshiki Kudo, Satoshi Tashiro, Takashi Yamamoto, Shinya Matsuura   +8 more
doaj   +1 more source

LGR5+ Intestinal Stem Cells Display Sex-Dependent Radiosensitivity

Cells, 2023
Tissue radiosensitivity plays a critical role in the overall outcome of radiation therapy. Identifying characteristics that predict how a patient may respond to radiotherapy enables clinicians to maximize the therapeutic window.
Ryan C. Zitter, Rishi Man Chugh, Payel Bhanja, Bruce F. Kimler, Subhrajit Saha   +4 more
doaj   +1 more source