Results 31 to 40 of about 5,403,021 (155)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

CYTOGENETIC STUDIES IN PATIENTS WITH UREMIA BEFORE HEMODIALYSIS (A PRELIMINARY STUDY)

Eurasian Journal of Medicine, 2019
This study has been planned to elucidate the effect of uremia on human genome. For this purpouse, on the mitotic metaphases obtained from the cultured periferic blood samples of 18 patient with uremia to be given hemodialysis treatment for the first time
Sıtkı Öztaş, Kamuran Turgut, İrfan Batat, Figen Keskinler, A. Gani Tatar   +4 more
doaj  

Radiosensitivity in individuals with tuberous sclerosis complex

Discover Oncology
Benign tumors, but rarely cancer, are common in patients with tuberous sclerosis complex (TSC). Blood samples from patients undergoing treatment for TSC at our institution were analyzed for their individual sensitivity to ionizing radiation.
Lukas Kuhlmann, Jenny Stritzelberger, Rainer Fietkau, Luitpold V. Distel, Hajo M. Hamer   +4 more
doaj   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

Implementing Course‐Based Undergraduate Research Experiences in Microscopy Education: A Four‐Year Development Journey

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Course‐based Undergraduate Research Experiences (CUREs) provide undergraduate students with opportunities to engage in novel scientific research as part of their core curriculum rather than as extracurricular activities. This paper describes the development, implementation, and evolution of a CURE‐based microscopy laboratory course over 4 ...
Michael Seifu Bahiru, Andrew D. Stephens
wiley   +1 more source

Captivated by Kinesin

Cytoskeleton, EarlyView.
ABSTRACT Few proteins have inspired as much curiosity as kinesin. Since its discovery 40 years ago, kinesin has become one of the best understood molecular machines in biology, yet it continues to reveal new questions about how cells organize and move their contents.
Ronald D. Vale
wiley   +1 more source

Combined Karyotyping, Copy Number Variation Sequencing, and Whole Exome Sequencing in the Prenatal Diagnosis of Congenital Heart Disease: Detection Rates and Phenotypic Associations

Journal of Clinical Laboratory Analysis, EarlyView.
This study combined karyotyping, copy number variation sequencing, and whole‐exome sequencing to assess the value of genetic testing in the prenatal diagnosis of congenital heart disease (CHD) and to evaluate the relationship between genetic variants and prenatal phenotypes.
Jieqiong Xie, Yanru Huang, Xingmei Yao, Lutan Zhang, Yixi Zhou, Wenbo Wang, Jian Zhang, Yunsheng Ge   +7 more
wiley   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Chromosome instability and hypersensitivity to DNA damage of UBR2-deficient somatic cells.

, 2012
(A) UBR2-knockdown induces hyperproliferation in HeLa cells. (B) Metaphase chromosomes of UBR2−/− MEFs show increased chromosomal aberrations, including breaks and fragmentations, compared with control cells.
Adriana Zakrzewska (164235), Jun Min Jang (164248), Min Jae Lee (164258), Tae-You Kim (73316), Jee Young An (164220), Euna Kim (164229), Bo Yeon Kim (164272), Yong Jun Lee (164265), Dirk G. de Rooij (47163), Yong Tae Kwon (164276), Young Dong Yoo (164242), Dong Hoon Han (164254), Jai Wha Seo (164261)   +12 more
core   +1 more source

Chromosome breakpoint distribution of damage induced in peripheral blood lymphocytes by densely ionising radiation [PDF]

, 2006
Purpose: To assess the chromosomal breakpoint distribution in human peripheral blood lymphocytes (PBL) after exposure to a low dose of high linear energy transfer (LET) α-particles using the technique of multiplex fluorescence in situ hybridisation (m ...
Anderson, RM, Papworth, DG, Sumption, ND, Goodhead, DT   +3 more
core   +1 more source