Results 41 to 50 of about 7,148,171 (303)

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim   +11 more
wiley   +1 more source

Uncovering Inequities: The Role of Social Determinants of Health in Hospitalized Adolescents and Young Adults With Heavy Menstrual Bleeding

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Heavy menstrual bleeding (HMB) is a common condition among adolescents and young adults (AYAs) and is the leading cause of iron deficiency anemia (IDA) in this population. Growing evidence suggests that social determinants of health (SDOH) influence menstrual bleeding patterns, access to care, and treatment. However, no studies have
Maria Carter‐Febres   +6 more
wiley   +1 more source

Rights and responsibilities: consultation report [PDF]

open access: yes, 2015
Rights & Responsibilities 2014 was a national consultation conducted by the Human Rights Commissioner between August and December 2014. The consultation examined how well people think their human rights and freedoms are protected in Australia ...
Australian Human Rights Commission
core  

Sexual orientation, gender identity and human rights in the Commonwealth: from history and law to developing activism and transnational dialogues [PDF]

open access: yes, 2013
Human rights in relation to sexual orientation and gender identity are at last reaching the heart of global debates. Yet 78 states worldwide continue to criminalise same-sex sexual behaviour, and due to the legal legacies of the British Empire, 42 of ...
Obendorf, Simon   +21 more
core   +1 more source

L'approche sociologique et anthropologique des questions de développement durable, de justice environnementale et de crimes environnementaux" (Analyse de contenu) [PDF]

open access: yesمجلة مستقبل العلوم الإجتماعیة
Various patterns of individual behaviors may go beyond mere predetermined automatic responses imposed by social rules, norms, and traditions (Social Norms) . They may reflect a meaningful interaction with the local environment.
حاتم الميلوشي
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

John Wilkes, the Wilkite Lawyers and Locke’s Appeal to Law

open access: yesJournal on European History of Law, 2015
England’s Wilkite movement of the 1760s has usually been viewed as a functional and instrumental effort to enlarge political consciousness and political participation through the use of new communicative strategies and techniques.
Michael Conforti
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

GLOBALIZATION, GLOBAL PROCESSES AND SECURITY ENVIRONMENT UNDER SUSTAINABLE DEVELOPMENT CONDITIONS [PDF]

open access: yesAnnals: Series on Military Sciences, 2013
The globalization, sustainable development and security environment are some terms which are daily used. On this background main theoretical initiatives appeared on correlation between national security and international security, having individual ...
Mircea UDRESCU   +2 more
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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