Results 61 to 70 of about 6,447 (214)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

GLOBALIZATION, GLOBAL PROCESSES AND SECURITY ENVIRONMENT UNDER SUSTAINABLE DEVELOPMENT CONDITIONS [PDF]

open access: yesAnnals: Series on Military Sciences, 2013
The globalization, sustainable development and security environment are some terms which are daily used. On this background main theoretical initiatives appeared on correlation between national security and international security, having individual ...
Mircea UDRESCU   +2 more
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Judicialization of Health Policy in the Definition of Access to Public Goods: Individual Rights versus Collective Rights

open access: yesBrazilian Political Science Review, 2010
The article analyses a form of judicialization of public policies in the health field. It has as its object lawsuits initiated against Belo Horizonte Municipality arguing for the provision of services or the acquisition of inputs not obtained in the ...
Telma Maria Gonçalves Menicucci   +1 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Cultural Practices and Constitutional Rights in Widowhood: Lived Experiences of Black Widowed Women in Makapanstad Village in South Africa

open access: yesSocial Sciences
This paper aims to examine the various cultural practices that apply to widows vis à vis their constitutional rights. The Constitution of the Republic of South Africa, 1996 (hereinafter referred to as the constitution) outlines inalienable human rights ...
Sizakele Matlabe-Danke
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Ethical Healthcare During Public Health Emergencies: A Focus on Non-COVID-19 Patients

open access: yesRisk Management and Healthcare Policy
Man Teng Iong Faculty of Law, University of Macau, Macao, People’s Republic of ChinaCorrespondence: Man Teng Iong, Faculty of Law (FLL), University of Macau, E32, Avenida da Universidade, Taipa, Macau, People’s Republic of China, Email mantengiong@um.edu.
Iong MT
doaj  

THE NEED FOR PROTECTION OF HUMAN RIGHTS IN CYBERSPACE

open access: yesJournal of Modern Science, 2019
Objectives Technology is an integral part of social life. The widespread use of computers and the development of information and communication technologies have made people dependent on this technology in many ways.
Iwona Barbara Florek   +1 more
doaj   +1 more source

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