Results 81 to 90 of about 7,148,171 (303)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
ETHICS BETWEEN INDIVIDUAL RIGHTS AND SOCIAL RESPONSIBILITIES. [PDF]
J Emerg Med, 2023 Giwa AO, Myers M, Urdaneta A.
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
, 2009 Title from title PDF cover (viewed on Dec. 23, 2009).; "Created: 10/2/2006 ...; Modified: 2/25/2009 ..."--Document properties screen.; "September 2006"--P.
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
MULTI-SPECIES INDIVIDUAL TRANSFERABLE QUOTAS: THE SCOTIA-FUNDY MOBILE GEAR GROUNDFISHERY [PDF]
Few studies examine the economic effects of individual harvesting rights in multi-species fisheries. Using costs and earnings data from a multispecies individual transferable quota (ITQ) fishery in Nova Scotia, before and after the introduction of ...
Dupont, Diane P., Grafton, R. Quentin
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Population preferences for non-pharmaceutical interventions to control the SARS-CoV-2 pandemic: trade-offs among public health, individual rights, and economics. [PDF]
Eur J Health Econ, 2022 Mühlbacher AC, Sadler A, Jordan Y.
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The European Convention on Human Rights and the Protection of the Roma as a Controversial Case of Cultural Diversity. EDAP 5/2004 [PDF]
, 2004 The Roma are often the victims of systemic discrimination which is closely related to the prejudices against them and their particular way of life, their own minority identity. When studying to what extent the Roma and their own way of life are protected
Henrard, Kristin.
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