Results 41 to 50 of about 258,169 (251)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evaluation of Interventions for Individuals with Special Needs After an Earthquake: Teacher Perspective

Sakarya University Journal of Education
Türkiye is in a geography where many large and small-scale earthquakes occur due to its location in the earthquake zone. The Kahramanmaraş earthquake on February 6, 2023, and the Hatay earthquake on February 20, 2023, affected individuals with special ...
Ayşe Büşra Subaşı Yurtçu, D. Merve Tuna, Fidan Güneş Gürgör Kılıç   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Barriers to Dental Care in Individuals with Special Healthcare Needs in Qatif, Saudi Arabia: A Caregiver’s Perspective

Patient Preference and Adherence, 2021
Amal Alfaraj,1 Hassan S Halawany,2 Muntasar T Al-Hinai,3 Abid H Al-Badr,2 Marwa Alalshaikh,4 Khalifa S Al-Khalifa5 1Prosthodontics Residency Program, Department of Prosthodontics, School of Dentistry, Indiana University, Indianapolis, IN, USA ...
Alfaraj A, Halawany HS, Al-Hinai MT, Al-Badr AH, Alalshaikh M, Al-Khalifa KS   +5 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Individualized Oral Hygiene Home Visits for Children With Special Needs

Special Care in Dentistry
AbstractObjectiveThis study aims to evaluate the 6‐month effects of an applied oral hygiene education program delivered through home visits for children with special needs in Istanbul. Additionally, the study seeks to establish an individualized oral health monitoring program and promote non‐cariogenic dietary habits.Methods and ResultsThe study ...
Tunalı, Esra, Ataş, Cafer, Çağ, Yakup, Orhan, Ahmet Lütfullah, Aydınbelge, Mustafa, Tunalı, Mustafa, Özen, Buğra   +6 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Individuals with special needs and their families’ oral health-related quality of life

Brazilian Oral Research, 2018
To evaluate the impact of dental caries among Brazilian individuals with special health care needs (SHCN) on their families’ oral health-related quality of life (OHRQoL).
Viviane Cancio, Khawana Faker, Cristiane Baccin Bendo, Saul Martins Paiva, Mônica Almeida Tostes   +4 more
doaj   +1 more source