Results 71 to 80 of about 258,169 (251)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Utilisation of dental services for people with special health care needs in Australia

BMC Oral Health, 2020
Background To explore the profile of patients and treatment delivered at specialist referral centres for individuals with special needs. Methods A cross-sectional audit was conducted of the health records of all patients with appointments at two of ...
Mathew Albert Wei Ting Lim, Sharon Andrea Corinne Liberali, Gelsomina Lucia Borromeo   +2 more
doaj   +1 more source

Nutrition for Individuals with Special Needs: Advocacy Guide

Special needs is a broad term that includes numerous conditions, such as children born with congenital conditions such as cerebral palsy, to a woman with chronic arthritis, to elderly individuals dealing with dementia, to anyone who lost one or more of their motor limbs in an accident or war.
Ayoub Al-Jawaldeh, Mandy Taktouk, Alaa Al-Bakheit, Amina Barkat, Hanin Al-Jawaldeh, Hazem Agha, Reema Tayyem   +6 more
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Sexual education for individuals with special needs: Understanding and overcoming current obstacles

Journal of Innovation in Polytechnic Education
Sexual education has often been a highly debatable, underrated, and undervalued topic. Efforts to address this neglect have yielded significant progress.
Anastasiia Melnikova
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Use of Montessori Education for Therapeutic Purposes in Individuals with Special Needs

Preschool Education: Global Trends
Introductıon. The main idea of Montessori Pedagogy and Montessori Therapy based on it is to contribute to the development of the child by accepting them with their own personality and providing special 'sensory development tools' and activities suitable ...
Safiye Sunay Yildirim Doğru, Hatice Bilge Doğru   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

EXAMINING THE RELATIONSHIP BETWEEN INTERNET ADDICTION AND AGGRESSIVE BEHAVIORS IN INDIVIDUALS WITH SPECIAL NEEDS (PARENTAL ASSESSMENT)

Turkish International Journal of Special Education and Guidance & Counselling
The aim of this research is to examine the relationship between internet addiction and aggressive behaviors among individuals with special needs attending special education in the Turkish Republic of Northern Cyprus (TRNC) and to determine whether this ...
Alperen DAĞTEKİN, Cahit NURİ, Başak BAĞLAMA   +2 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source