Results 111 to 120 of about 16,631 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2013 International audienceIn his text, A theatre of individuation, B. Stiegler (2012) contends that Simondon ignored that alongside processes on individuation there are also processes of de-individuation.
Moriceau, Jean-Luc
core
Frontiers in Cellular and Infection MicrobiologyOsteoporosis, arthritis, and fractures are examples of orthopedic illnesses that not only significantly impair patients’ quality of life but also complicate and raise the expense of therapy. It has been discovered in recent years that the pathophysiology
Zhuce Shao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Aquinas\u27 Principle of Individuation
, 2017 The author notices ambiguity in Aquinas’ principle of individuation, or how it is that a universal substantial form becomes instantiated in primary substances yet remains universal (to the class).
Hughes, Patrick W.
core
Individuation and Movements of Existence in Jan Patočka
Theology and Philosophy of EducationJan Patočka addresses the concept of individuation in relation to the three movements of existence. This article argues that education functions as a process of individuation, requiring educators to engage with the third movement of existence in order ...
Lina Marcela Gil-Congote
doaj
Individual Home Advantage with Individual Data
, 2021 Home advantage (HA) is a well-documented phenomenon in (professional) team sports. However, there is also a growing body of evidence that in individual sports home athletes have an advantage. I define HA as ‘the performance advantage of an athlete, team, or country when they compete at a home ground compared to their performance under similar ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source