Results 121 to 130 of about 16,631 (311)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
OAB Individuation instruction Categorization Data
, 2019 Data for project - Individuation and categorization in the ...
Belinda Craig
core +1 more source
Yesus Kristus sebagai Arketipe Gereja: Menuju Gereja yang Terbuka Terhadap LGBT
Gema TeologikaThis paper challenges the church’s exclusion of LGBT individuals, who have been deemed sinners and thus unworthy of participating in ecclesiastical communion.
Yosia Polando Ressa
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2002 The object of this study is to conduct a Jungian interpretation of Euripides' dramatic play Medea and Medea's role in the story of Jason and the Argonauts in terms of Jung's concept of individuation.
Glines, Cynthia
core
Sens et conditions des crises de la forme scolaire et de son évolution
Penser l'ÉducationThe observation of a crisis of the school form predominates today in scholarly literature and opinion, but how to objectify it? For philosophy, such a diagnosis brings together questions at the same time axiological, epistemological and political, even ...
Emmanuel Brassat
doaj +1 more source