Results 151 to 160 of about 288,739 (291)

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Fused Indole-Diazepines with a Bridgehead Nitrogen Atom: Synthesis and Pharmaceutical Significance. [PDF]

Drug Des Devel Ther
Zhou M, Yang X, Wang S.
europepmc   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Mechanisms by which tryptophan metabolites enhance intestinal barrier function to prevent necrotizing enterocolitis in preterm infants. [PDF]

Front Immunol
Cui X, Qiu J, Xu Y, Guan Z, Ding Y, Yu S, Fan S, Song G, Ren X.   +8 more
europepmc   +1 more source

Probing the Influence of Sulfur–Aromatic Interactions on the Electronic Structure of Gas‐Phase Peptides

Chemistry – A European Journal, EarlyView.
Just as fingerprints reveal identity, spectroscopic fingerprints reveal molecular secrets. In this article, we show parts of the unique fingerprint of the sulfur–aromatic interaction. By measuring how this force alters the electronic structure of gas‐phase peptides, we provide a fundamental understanding of interactions that give insights into the ...
Laura Pille, Carlos Ortiz‐Mahecha, Bart Oostenrijk, Juliette Leroux, Marion Girod, Konstantin Hirsch, Luke MacAleese, Robert Horst Meißner, Debora Scuderi, Isaak Unger, Vicente Zamudio‐Bayer, Sadia Bari, Lucas Schwob   +12 more
wiley   +1 more source

Gravid <i>Anopheles stephensi</i> Detects Indole for Oviposition Despite the Ablation of Antennae and Maxillary Palps. [PDF]

Insects
Agbetsi J, Xu J.
europepmc   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source

<i>O</i>-Heterocycles-Fused Indoles via Tandem 1,2-Indole Migration-Hydroxycyclization Reactions in 2-Hydroxyalkyl-3-propargylindoles. [PDF]

Org Lett
Renedo L, Solas M, Silva López C, Suárez-Pantiga S, Sanz R.   +4 more
europepmc   +1 more source

Photoinduced Hydrogenative Dearomatization With Homocoupling of Quinolines to Construct Octahydro‐4,4'‐biquinolines

Chemistry – A European Journal, EarlyView.
Dearomative homocoupling of quinolines into 1,1',2,2',3,3',4,4'‐octahydro‐4,4'‐biquinoline (OHBQ) is reported. The photoexcited boron complex, in situ generated from quinoline, HB(pin), and KOtBu, enables the unprecedented homocoupling of tetrahydroquinolines that is challenging in the ground state, expanding the chemical diversity of OHBQ derivatives.
Mone Suzuki, Asuha Shimose, Yuki Nagashima   +2 more
wiley   +1 more source

Host-derived nitrate fuels indole production by <i>Escherichia coli</i> to drive chronic kidney disease progression. [PDF]

Science
Lee JY, Mahan SP, Parente de Carvalho T, Nguyen H, Singai C, Camacho L, Tekeli M, Kwon YJ, Lee JW, Santos RL, Tsolis RM, Winter SE, Bäumler AJ.   +12 more
europepmc   +1 more source