Results 191 to 200 of about 140,654 (327)

Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy. [PDF]

Nat Commun
De Juan A, Coillard A, Cros A, Rigamonti A, Alaoui L, Sampaio JL, Monot N, Balvay A, Foussier A, Rieux-Laucat M, Guyonnet L, Rabot S, Vosshenrich C, Segura E.   +13 more
europepmc   +1 more source

Podophyllotoxin analogue with bicyclo[3.2.1]octane moiety annelated with indole: synthesis, molecular modeling, and biological testing

, 2019
N. A. Zefirov, E. A. Lavrushkina, С. А. Кузнецов, O. N. Zefirova   +3 more
openalex   +2 more sources

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Chemistry – A European Journal, EarlyView.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger, Nika Podlesnik, Francesco Mele, Michael Schnürch   +3 more
wiley   +1 more source

Alterations in Tryptophan Metabolism and the Indole Pathway in Colorectal Cancer Patients: A Systematic Review and Meta-analysis. [PDF]

MedComm (2020)
Griffith L, Sinha A, Acharjee A.
europepmc   +1 more source

Dual Ligand‐Enabled Nondirected C─H Olefination of (Hetero)Arenes for the Synthesis of Clickable Derivatives

Chemistry – A European Journal, EarlyView.
We report an efficient method for late‐stage installation of “clickable” alkyne groups into diverse (hetero)arenes. Using a dual‐ligand palladium catalyst that combines an NASA ligand with an N‐heterocycle, an acrylate unit bearing a terminal alkyne can be introduced via nondirected C─H activation.
Tommaso Braga, Maria Hergert, Manuel van Gemmeren   +2 more
wiley   +1 more source

Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice. [PDF]

Cells
Szabó Á, Galla Z, Spekker E, Martos D, Szűcs M, Fejes-Szabó A, Fehér Á, Takeda K, Ozaki K, Inoue H, Yamamoto S, Monostori P, Toldi J, Ono E, Vécsei L, Tanaka M.   +15 more
europepmc   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Integrated genome mining and phytohormone profiling of six plant growth-promoting elite bacterial strains. [PDF]

Arch Microbiol
Ercole TG, Liviero R, Terra LA, Zocolo GJ, Klepa MS, Ribeiro RA, Nogueira MA, Hungria M.   +7 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Untargeted metabolomics identifies a bacterial cyclic dipeptide that induces resistance to a rust fungus of beans. [PDF]

Sci Rep
Cooper B, Yang R, Campbell KB.
europepmc   +1 more source