Results 231 to 240 of about 140,654 (327)

A novel mechanism of auxin habituation: upregulation of auxin receptor TRANSPORT INHIBITOR RESPONSE 1 allows cell proliferation independent of external auxin. [PDF]

New Phytol
Jelínek P, Müller K, Kobercová E, Přibylová A, Čovanová M, Dobrev PI, Vaculíková R, Vondráková Z, Helusová L, Bírošíková A, Fischer L, Petrášek J.   +11 more
europepmc   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Activation of aryl hydrocarbon receptor signaling by indole-3-lactic acid from Bacillus velezensis DS2 reinforces gut mucosal immunity and attenuates inflammaging in aged mice. [PDF]

Immun Ageing
Liu X, Zhou J, Hou Q, Zhou Z, Bai Y.
europepmc   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation. [PDF]

Chem Biodivers
Pinheiro NAP, Romão IC, Alves AMB, Siqueira SMC, de Menezes JESA, Marinho ES, Ferreira MKA, Marinho MM, de Sousa Magalhães H, de Castro Gomes AF, Pessoa ODL, Dos Santos HS.   +11 more
europepmc   +1 more source

Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish

iMeta, EarlyView.
Evidence for liver metabolism of gut‐derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mannose supplementation under high‐fat diet conditions, convert arginine into putrescine.
Delong Meng, Zhen Zhang, Tsegay Teame, Benjamin Earl Niemann, Rui Xia, Shichang Xu, Yajie Zhao, Yalin Yang, Chao Ran, Le Luo Guan, Zhigang Zhou   +10 more
wiley   +1 more source

Synthesis and Evaluation of Radioiodinated [¹²⁵I]7-Iodo-5H-Pyrido[4,3-B]Indole ([¹²⁵I]CTAU) in Postmortem Human Alzheimer's Disease Brain. [PDF]

J Labelled Comp Radiopharm
McNamara CC, Biju AP, Hipolito ELM, Nguyen NTB, Liang C, Mukherjee J.   +5 more
europepmc   +1 more source

Plasmonics‐Enhanced Characterization of Cervid PrP (87–114) Fragment Aggregates in Solution

Journal of Biophotonics, EarlyView.
Multimodal nanophotonics platform combining plasmon‐enhanced imaging, label‐free SERS, and optical staining reveals new insights into the aggregation of the cervid PrP (87–114) fragment, an amyloidogenic sequence linked to chronic wasting disease susceptibility.
Shinki Midha, Aishwarya Sriraman, Lyudmyla Dorosh, Holger Wille, Maria Stepanova   +4 more
wiley   +1 more source

Indole-3-propionic acid exacerbates cisplatin-induced chronic kidney disease through the AHR/NF-κB signaling pathway. [PDF]

iScience
Wang Q, Chen J, Chen H, Liang D, Zhou H, Chen J, Gui Y, Yao F, Chen Y, Zeng X, Ma Y, Zhou D, Fu H.   +12 more
europepmc   +1 more source

Indole‐Based π‐Extended Monophosphine Ligands for Enhanced Palladium‐Catalyzed Sonogashira Coupling

Journal of Heterocyclic Chemistry, EarlyView.
A general palladium‐catalyzed Sonogashira cross‐coupling of (hetero)aryl chlorides with aliphatic, (hetero)aryl alkynes is described using Pd(dba)₂/PCy2‐Napdole‐phos catalyst system. The reaction protocol exhibits broad substrate scope and the catalyst loading can be down to 0.2 mol% Pd.
Yu Kiu Lau, Chun Pong Hui, Cheuk Long Li, Ho Chung Chang, Man Ho Tse, Ho Kwan Lou, Iat In Chan, Raymond Wai‐Yin Sun, Pui Ying Choy, Fuk Yee Kwong   +9 more
wiley   +1 more source