Results 251 to 260 of about 140,654 (327)

Bioinspired, Guanidinium, and Indole Modified Poly(glycidyl ether)s as Highly Efficient Vectors for Polyplex‐Mediated Gene Delivery

Macromolecular Rapid Communications, EarlyView.
Guanidinium‐ and indole‐functionalized poly(glycidyl ether)s were developed as non‐viral gene delivery vectors with tunable hydrophilic–hydrophobic balance. All polymers formed stable DNA polyplexes, while moderate indole content yielded the highest transfection efficiency at low N/P ratios.
Markus Kötzsche, Andreas Dzierza, Lennert Sölter, Jan Egger, Kjell Cornelis, Andreas Stihl, Felix H. Schacher, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance in <i>Lentinula edodes</i> mycelia subjected to heat stress. [PDF]

Microbiol Spectr
Wei X, Song J, Chen J, Xiao Y, Zhou Y, Bian Y, Gong Y.   +6 more
europepmc   +1 more source

Olfactory physiology of blood-feeding vector mosquitoes [PDF]

, 2010
Loon, J.J.A., van, Qiu, Y.T.
core   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Indole-3-aldehyde Preserves Gingival Epithelial Barrier Structure and Function Via AhR/Nrf2 Signaling Pathway. [PDF]

Inflammation
Wu L, Wu S, Deng Y, Li J, Zhang C, Wang Y, Zhao C, Gao L.   +7 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Tryptophan catabolites from microbiota ameliorate immune-mediated hepatitis through activating aryl hydrocarbon receptor of T cells. [PDF]

Gut Microbes
Li B, Liang X, Li Y, Wang R, Wei Y, Liu Q, Zhang J, Wang Q, Miao Q, Xiao X, Lian M, Wang Z, Zhou Y, Gershwin ME, You Z, Tang R, Ma X.   +16 more
europepmc   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, EarlyView.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease

The Journal of Pathology, EarlyView.
Abstract Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobiology between mice and humans underscore the need for alternative mammalian models that better ...
Daniel W. Hart, Aik Seng Ng, Patrycja Gazińska, Robert Goldin, Purva Gopal, Nicolize O'Dell, Ahmad Zargar, Lior Pytowski, Shamir Montazid, Chiara Bardella, James E. East, Ian P. Tomlinson, Nadine Koch, Nigel C. Bennett, Shazia Irshad   +14 more
wiley   +1 more source

Design, Synthesis and Anticancer Activity of 6-Substituted-1-(3,4,5-trimethoxyphenyl)-<i>1H</i>-indole Against Tubulin Polymerisation. [PDF]

Molecules
Gu Y, Gai C, Zou S, Song Y, Zhang J, Zhao Q, Chai X, Wang P.   +7 more
europepmc   +1 more source