Results 41 to 50 of about 3,209 (136)

Toward the development of small molecules for unconventional targets and diseases [PDF]

, 2019
This thesis is focused on the development of small molecules for unconventional targets and diseases: the Store-Operated Calcium Entry (SOCE) machinery, the enzyme indoleamine 2,3 dioxygenase 1 (IDO1) and hereditary multiple exostoses (HME) disease.
Griglio, Alessia
core   +1 more source

Immune‐dysregulation harnessing in myeloid neoplasms

Cancer Medicine, Volume 13, Issue 17, September 2024.
Abstract Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in bone marrow microenvironments.
Mohammad Jafar Sharifi, Ling Xu, Nahid Nasiri, Mehnoosh Ashja‐Arvan, Hadis Soleimanzadeh, Mazdak Ganjalikhani‐Hakemi   +5 more
wiley   +1 more source

Xanthurenic acid: A role in brain intercellular signaling

Journal of Neurochemistry, Volume 168, Issue 9, Page 2303-2315, September 2024.
The two compounds are structural analogues and the level of XA is regulated by the activity of KMO producing the precursor 3‐hydroxykynurenine. XA accumulates in neurons, while KYNA is present in astrocytes. Unknown factors regulate the release of each of these compounds.
Michel Maitre, Omar Taleb, Hélène Jeltsch‐David, Christian Klein, Ayikoe‐Guy Mensah‐Nyagan   +4 more
wiley   +1 more source

The role of tryptophan metabolism and tolerogenic dendritic cells in maintaining immune tolerance: Insights into celiac disease pathogenesis

Immunity, Inflammation and Disease, Volume 12, Issue 8, August 2024.
Tryptophan, one of the eight essential amino acids, has evolved as a primary regulatory node in controlling immune responses. Celiac disease (CeD) is a developed immunological condition caused by gluten intolerance. Tolerogenic dendritic cells emerge as pivotal conductors, inducing immune tolerance and facilitating T‐reg differentiation to safeguard ...
Fatemeh Asgari, Mahdi Khodadoust, Abdolrahim Nikzamir, Somayeh Jahani‐Sherafat, Mostafa Rezaei Tavirani, Mohammad Rostami‐Nejad   +5 more
wiley   +1 more source

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell [PDF]

, 2009
Background Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates.
D'Elia, Riccardo, deSchoolmeester, Matthew L, Else, Kathryn J, Pemberton, Alan D, Wright, Steven H, Zeef, Leo AH   +5 more
core   +4 more sources

Periodontal granulation tissue – To remove or not to remove, that is the question

Journal of Periodontal Research, Volume 59, Issue 4, Page 636-646, August 2024.
Abstract Formation of granulation tissue is a fundamental phase in periodontal wound healing with subsequent maturation leading to regeneration or repair. However, persistently inflamed granulation tissue presents in osseous defects as a result of periodontitis and is routinely disrupted and discarded with non‐surgical and surgical therapy to ...
Ye Han Sam, Luigi Nibali, Mandeep Ghuman
wiley   +1 more source

Abstracts

, 2023
Molecular Oncology, Volume 17, Issue S1, Page 1-597, June 2023.
wiley   +1 more source

Probing the Ternary Complexes of Indoleamine and Tryptophan 2,3-Dioxygenases by Cryoreduction EPR and ENDOR Spectroscopy [PDF]

, 2010
We have applied cryoreduction/EPR/ENDOR techniques to characterize the active-site structure of the ferrous-oxy complexes of human (hIDO) and Shewanella oneidensis (sIDO) indoleamine 2,3-dioxygenases, Xanthomonas campestris (XcTDO) tryptophan 2,3 ...
Basran J., Batabyal D., Batabyal D., Berry E. A., Bradford M. M., Brady F. O., Chauhan N., Chauhan N., Chung L. W., Davydov R., Davydov R., Davydov R., Davydov R., Davydov R., Davydov R., Davydov R., Fahnenschmidt M., Forouhar F., Garcia-Serres R., Glasoe P. K., Joule J. A., Kappl R., Kawamichi H., Lewis-Ballester A., Papadopoulou N. D., Scholes C. P., Sono M., Sugimoto H., Suzuki T., Suzuki T., Suzuki T., Terentis A. C., Thackray S. J., Uchida K., Zhang Y.   +34 more
core   +2 more sources

Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment

Molecular Oncology, Volume 18, Issue 7, Page 1695-1718, July 2024.
T cells engineered to express chimeric antigen receptors (CAR) are dependent on the transport and utilization of nutrients from the extracellular space, fueling their anti‐tumor activity. Nonetheless, the tumor microenvironment is characterized by a dearth of several key nutrients and alterations in metabolic scavenging systems.
Josquin Moraly, Taisuke Kondo, Mehdi Benzaoui, Justyn DuSold, Sohan Talluri, Marie C. Pouzolles, Christopher Chien, Valérie Dardalhon, Naomi Taylor   +8 more
wiley   +1 more source

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening [PDF]

, 2019
Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients' immune systems, leading to poor disease outcomes. Both
Leung, E, Reynisson, J, Sari, S, Tomek, P   +3 more
core   +1 more source